Anti-DNA/RNA Damage antibody [15A3] ab62623 from Abcam

Product Specs
ItemAnti-DNA/RNA Damage antibody [15A3]
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab62623
Antibody TypePrimary
ClonalityMonoclonal
IsotypeIgG2b
Clone15A3
Quantity100 UG
ApplicationsAffinity purification, ELISA, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunohistochemistry (Frozen sections)
HostMouse, Nude mouse
Conjugate/TagUnconjugated
Concentration1 mg/ml
ReactivitySpecies independent
TargetDNA/RNA Damage

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activationSci AdvDecember 6, 2023Wei Xiang, Hongwei Lv, Fuxue Xing, Xiaoyan Sun, Yue Ma, Lu Wu, Guishuai Lv, Qianni Zong, Liang Wang, Zixin Wu, et al.(ab40793), αPD-L1 (ab213480), anti-HSP60 (ab46798), anti-dsDNA (ab27156), anti-DNA damage (8-OHdG) (ab62623), anti-Ki67 (ab16667), and anti-CD8 (ab93278) were purchased from Abcam. Anti-cGAS (sc-515802) was purchased

(2) Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male RatsAntioxidants (Basel)October 3, 2023Daiane Cattani, Paula Pierozan, Ariane Zamoner, Eva Brittebo, Oskar Karlssonantibodies anti-4 hydroxynonenal (ab46544), anti-NeuN (ab177487), anti-GFAP (ab4674), anti-DNA/RNA damage (ab62623), anti-Tyrosine Hydroxylase (ab6211), and the secondary antibodies donkey anti-rabbit IgG H&L Alexa Fluor® 555

(3) Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulationAging cellSeptember 1, 2023Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, et al.2022). Primary antibodies against rabbit anti‐Nrf2 (Proteintech, 16,396‐1‐AP), Mouse anti‐8‐OHdG (Abcam, ab62623), rabbit anti‐p16 (Abcam, ab211542), rabbit anti‐IL‐6 (Santa Cruz, sc‐1265), and rabbit anti‐IL‐1β (Abcam,

(4) D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of miceBMC Mol Cell BiolAugust 21, 2023Zhe Peng, Chunli Zhao, Zijing Yang, Shusheng Gong, Zhengde Duovernight at 4 °C with primary antibodies: monoclonal mouse anti-8-OHdG (diluted 1:200; Abcam, USA, Cat.No#ab62623), anti-NOX2 (diluted 1:200; Invitrogen, Waltham, MA, USA, Cat.No#PA5-76034,), anti-UCP2 (diluted 1:200;

(5) Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancerCell Death DisAugust 18, 2023Soon Young Park, Kang Jin Jeong, Alfonso Poire, Dong Zhang, Yiu Huen Tsang, Aurora S. Blucher, Gordon B. Millsbuffer, pH 6.0), and blocked with 5% normal goat serum/PBS [40]. Primary antibodies (8-OHdG (Abcam, ab62623), p-RPA32 (Bethyl, A300-245A)) were incubated overnight at 4 °C, followed by incubation with secondary

(6) BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injuryFront NeurosciAugust 10, 2023Emily Leung, Daria Taskina, Nicole Schwab, Lili-Naz Hazratidetection of 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanine, and 8-hydroxyguanosine (1:4,000, Abcam ab62623). Membranes were washed 3 times for 5 min in PBST, followed by a 2 h incubation at room temperature

(7) Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivationChinese medicineJuly 18, 2023Wei H, Liu B, Yin C, Zeng D, Nie H, Li Y, Tai Y, He X, Liu B.#ab191860, Abcam), NLRP3 (1:800, #NBP2-12446, Novus), Caspase-1 (1:1000, #24232s, CST) and 4-HNE (1:500, #ab62623, Abcam). Subsequently, the immunoblots were incubated with the secondary antibodies for 2 h at room

(8) Co-administration of alcohol and combination antiretroviral therapy (cART) in male Sprague Dawley rats: A study on testicular morphology, oxidative and cytokines perturbationsAnatomy & Cell BiologyJune 30, 2023Elna Owembabazi, Pilani Nkomozepi, Tanya Calvey, Ejikeme Felix Mbajiorguinterleukin-6 (IL-6) (ab9324), malondialdehyde (MDA) (ab243066), and 8-hydroxydeoxyguanosine (8-OHDG) (ab62623) were procured from Abcam . Whilst biotinylated goat anti-rabbit (BA-1000) and goat anti-mouse (BA-9200)

(9) Role of NADPH Oxidase 4 in Corneal Endothelial Cells Is Mediated by Endoplasmic Reticulum Stress and AutophagyAntioxidants (Basel)June 7, 2023Dae Joong Ma, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Kyoung Wook Kim, Young Joo Shinmouse anti-NOX4 antibody (MABC616, Merck Millipore, Burlington, MA, USA), mouse anti-8-OHdG antibody (ab62623, Abcam, Cambridge, UK), rabbit anti-human NF-κB antibody (sc-372; Santa Cruz Biotechnology, Santa Cruz,

(10) CZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effectsScientific ReportsApril 13, 2023Haodong Chen, Yangbo Liu, Juling Feng, Hongyun Wang, Yantao Yang, Qidi Ai, Zhao Zhang, Shifeng Chu, Naihong Chenantibodies Nrf2 (ab62352, 1:1000 dilution; ab31163, 1:200 dilution) and 8-hydroxy-2’-deoxyguanosine (8-OHdG, ab62623, 1:100 dilution) were acquired by Abcam (Cambridge, UK); β-actin (AC038, 1:10,000 dilution) and NAD(P)H:

(11) Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapyJournal of nanobiotechnologyFebruary 10, 2023Zhu TT, Wang H, Gu HW, Ju LS, Wu XM, Pan WT, Zhao MM, Yang JJ, Liu PM.followed by incubation with primary antibody against Iba1 (1 μg/ml, 019-19741, Wako) or 8-OHDG (5 μg/ml, AB62623, Abcam) overnight at 4 °C. Next, wash the sections three times with PBS before incubating them with

(12) Secondary Degeneration of Oligodendrocyte Precursor Cells Occurs as Early as 24 h after Optic Nerve Injury in RatsInternational journal of molecular sciencesFebruary 9, 2023Toomey LM, Papini MG, Clarke TO, Wright AJ, Denham E, Warnock A, McGonigle T, Bartlett CA, Fitzgerald M, Anyaegbu CC.20 min at room temperature. Primary antibodies used recognized: 8OHDG (1:250, 4 µg/mL, mouse, Abcam, ab62623, GR3284216-13), rat Immunoglobulin G (IgG, 1:150, 10 µg/mL, goat, BA-9400, ZG0108, Vector Laboratories,

(13) Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhageFrontiers in immunologyJanuary 1, 2023Yang Y, Ding H, Yang C, Wu J, Bao Y, Lan S, Zhou L, Zhou L, Liu B, Hong T, et al.antibodies to sestrin2 (1:100, 21346-1-AP, Proteintech), Nrf2 (1:100, ab31163, Abcam), 8-ohdg (1:100, ab62623, Abcam), Iba-1 (1:50, SC-98468, Santa Cruz; 1:100, ab178847, Abcam), CD16 (1:100, BD Biosciences), and

(14) Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye DiseaseInternational journal of nanomedicineJanuary 1, 2023Lou Q, Pan L, Xiang S, Li Y, Jin J, Tan J, Huang B, Nan K, Lin S.antibodies used in this study were listed as follows: mouse anti-DNA/RNA Damage (1:100, Abcam, RRID: ab62623); rabbit anti-NLRP3 (1:100, GeneTex, RRID: GTX00763); rabbit anti-IL-1 β (1:100, Protein tech, RRID:

(15) Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c miceBMC Complementary Medicine and TherapiesDecember 1, 2022Abilasha Gayani Jayathilake, Elif Kadife, Nyanbol Kuol, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun Surabbit, 9542), (all from Cell Signaling Technology, USA), DNA/RNA damage (1:500, mouse, anti-8-OHdG mAB, ab62623 [15A3], Abcam, USA), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (1:2000 dilution, rabbit,

(16) Complement C3 deficiency alleviates alkylation-induced retinal degeneration in miceEye and VisionDecember 1, 2022Lu Du, Guang-Hua Peng(anti-rhodopsin, ab221664, 1:600; anti-C3, ab225539, 1:600; mouse monoclonal anti-DNA/RNA Damage [15A3], ab62623, 1:600). All sections were stained under the same conditions. Negative control slides (no primary antibody)

(17) Investigating key factors underlying neurodegeneration linked to alphaâ€synuclein spreadNeuropathology and Applied NeurobiologyOctober 1, 2022Cindy C. C. Pang, Maja H. SÃ¸rensen, Krit Lee, Kelvin C. Luk, John Q. Trojanowski, Virginia M. Y. Lee, Wendy Noble, Raymond C. C. Chang(Peter Davies 1:100), tau pS404 (Thermo scientific #44‐758G, 1:20), 8‐hydroxy‐2‐deoxyguanosine (Abcam #ab62623, 1:150) and anti‐nitrotyrosine antibody (Thermo scientific #A‐21285, 1:500) [47]. Western blot Western blot

(18) Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcriptionAging CellAugust 1, 2022Jiawen Zhou et al.Santa Cruz Biotechnology), acetyl‐histone H3 (Lys9/Lys14; #9677; Cell Signaling Technology), 8‐OHdG (ab62623; Abcam), IL‐1β (ab9722; Abcam), CD3e (sc‐20,047; Santa Cruz Biotechnology), IL‐6 (sc‐1265; Santa Cruz Biotechnology

(19) Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later lifeNature communicationsJuly 27, 2022Selle J, Dinger K, Jentgen V, Zanetti D, Will J, Georgomanolis T, Vohlen C, Wilke R, Kojonazarov B, Klymenko O, et al.(S139, γH2AX; Cell Signaling, #2577, 1:400, Danvers, MA, USA), monoclonal mouse anit-8-Oxo-dG (Abcam, #ab62623, clone 15A3, 1:400, Cambridge, UK) diluted in antibody diluent (DAKO, #S0809, Santa Clara, CA, USA).

(20) Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic RetinopathyAntioxidants (Basel, Switzerland)July 21, 2022Ramos H, Bogdanov P, Huerta J, Deàs-Just A, Hernández C, Simó R.Primary Antibodies,Description 8-Hydroxyguanosine,"Mouse monoclonal; 1:100; ab62623; Abcam, Cambridge, UK" Collagen IV,"Rabbit monoclonal; 1:200; ab236640; Abcam, Cambridge, UK" Copper-zinc

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Anti-DNA/RNA Damage antibody [15A3] from Abcam

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Anti-DNA/RNA Damage antibody [15A3] from Abcam

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