Fig 2: Correlation of ALDH1B1 and prognosis. (A,B) Locally advanced NPC patients with high ALDH1B1 expression had an unfavorable prognosis both in PFS and OS (P=0.017 and P<0.001, respectively). (C) No significant difference was found between ALDH1B1 expression and DFS in HNSC patients. (D) HNSC patients with high ALDH1B1 expression had a worse prognosis in OS (P=0.0034). ALDH1B1, aldehyde dehydrogenase 1B1; NPC, nasopharyngeal carcinoma; PFS, progression-free survival; OS, overall survival; DFS, disease-free survival; HNSC, head and neck squamous cell carcinoma.

Fig 3: IHC staining of ALDH1B1 expressions in locally advanced NPC and chronic nasopharyngitis tissues (upper: magnification 100×, lower: magnification 400×). (A) ALDH1B1 expression in chronic nasopharyngitis tissues. (B) Low ALDH1B1 expression in locally advanced NPC tissues. (C) High ALDH1B1 expression in locally advanced NPC tissues. IHC, immunohistochemistry; ALDH1B1, aldehyde dehydrogenase 1B1; NPC, nasopharyngeal carcinoma.