Anti-Hsc70 antibody [EP1531Y] ab51052 from Abcam

Product Specs
ItemAnti-Hsc70 antibody [EP1531Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab51052
Antibody TypePrimary
HostRabbit
Quantity10 UL, 40 UL, 100 UL
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot
ClonalityMonoclonal
IsotypeIgG
CloneEP1531Y
Conjugate/TagUnconjugated
Gene NameHSPA8
ValidationKnockOut Validated
ReactivityHuman, Mouse, Rat
TargetHsc70

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Phone: +44 (0) 1223 696000 (option 1)
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+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Elevated stress response marks deeply quiescent reserve cells of gastric chief cellsCommunications BiologyNovember 20, 2023Daisuke Shiokawa, Hiroaki Sakai, Miho Koizumi, Yoshie Okimoto, Yutaro Mori, Yusuke Kanda, Hirokazu Ohata, Hiroaki Honda, Koji OkamotoInvitrogen, MA5-36190); rabbit anti-Atf4 (1:100; Bioss, bs-1531R); rabbit anti-Hspa8 (1:100; Abcam, ab51052); and rabbit anti-Furin (1:100; Cell Signaling, #04709). Subsequently, the slides were stained with

(2) Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathwayScience AdvancesOctober 6, 2023Jin Wu, Yingying Han, Hao Xu, Hongyang Sun, Rui Wang, Haigang Ren, Guanghui Wanganti-p300 (sc-48343), anti-MAP2 (sc-20172) (Santa Cruz Biotechnology, Santa Cruz, CA, USA), or anti-HSC70 (ab51052), and anti-LAMP2A (ab18528) (Abcam, Cambridge, MA, USA) at 4°C overnight, followed by incubation with

(3) Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1−/− (yotari) MiceBiomoleculesFebruary 21, 2023Mirko Maglica, Nela Kelam, Ejazul Haque, Ilija Perutina, Anita Racetin, Natalija Filipović, Yu Katsuyama, Katarina VukojevićUK)" Primary,Anti-GRP78/PA5-19503,Rabbit,1:300,"Thermo Fisher Scientific (Waltham, MA, USA)" Primary,Ani-HSC70/ab51052,Rabbit,1:50,"Abcam (Cambridge, UK)" Primary,Anti-LAMP2A/ab18528,Rabbit,1:100,"Abcam (Cambridge, UK)" Secondary,"Anti-Rabbit

(4) NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosisCell Death DiscoveryDecember 1, 2022Li Li, Dongming Wu, Shihua Deng, Jin Li, Feng Zhang, Ye Zou, Ting Zhang, Ying XuProteintech (Wuhan, China). Antibodies against Lamp-2a (ab125068), HSP90 (ab32568), GPX4 (ab252833), HSC70(ab51052), and 4-HNE (ab46545) were obtained from Abcam (Cambridge, UK). NVP-AUY922 and ferrostatin-1 (Fer-1)

(5) Differential Size Distribution and Estrogen Receptor Cargo of Oviductal Extracellular Vesicles at Various Stages of Estrous Cycle in MiceReproductive SciencesOctober 1, 2022Chenchen Yi, Ya Ni, Peibei Sun, Tian Gao, Kun Lianti-CD9 antibody (EPR2949, ab92726; Abcam, Shanghai, China), rabbit monoclonal anti-Hsc70 antibody (EP1531Y, ab51052; Abcam, Shanghai, China), and rabbit monoclonal anti-ER alpha antibody (E115, ab32063; Abcam, Shanghai,

(6) Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8Redox BiologyAugust 1, 2022Yingmin Zhang, Xinhua Qiao, Lihui Liu, Wensheng Han, Qinghua Liu, Yuanyuan Wang, Ting Xie, Yiheng Tang, Tiepeng Wang, Jiao Meng, et al.were then incubated with the following primary antibodies overnight at 4 °C, anti-HSPA8 (Abcam, Cat. # ab51052); anti-P16 (ABclonal, Cat. # A0262), anti-P21 (ABclonal, Cat. # A19094), anti-P38 (Cell Signaling Technology,

(7) Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative responseAging cellJune 1, 2022Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q.anti‐LAMP2A (cat # ab125068, Abcam), anti‐LAMP1 (cat # 9091, Cell Signaling Technology), anti‐Hsc70 (cat # ab51052, Abcam), anti‐Nrf2 (cat # 16296‐1‐AP, Proteintech), anti‐Keap1 (cat # 10503‐2‐AP & cat # 60027‐1‐Ig,

(8) Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2Frontiers in oncologyJanuary 1, 2022Rai R, Chandra V, Kennedy AL, Zuna RE, Benbrook DM.purchased from Thermo Fisher Scientific and Biorbyt, respectively. The primary antibody to hsc70 [EP1531Y] (ab51052) was purchased from Abcam. After three times washing with TBST, the membranes were incubated with horse

(9) Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targetsNature cell biologyDecember 1, 2021Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, et al.(ab96696), anti-LDHB (clone 60H11; ab85319), anti-GPI (clone 1B7D7; ab66340), anti-HSPA8 (clone EP1531Y; ab51052), anti-PCSK9 (clone EPR7627(2); ab181142), anti-VPS35 (clone EPR11501(B); ab157220) and anti-MVP (clone

(10) Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based DisaggregaseInternational Journal of Molecular SciencesNovember 30, 2021Aitor Franco, Jorge Cuéllar, José Ángel Fernández-Higuero, Igor de la Arada, Natalia Orozco, José M. Valpuesta, Adelina Prado, Arturo MugaPA5-85343, 1:2000 dilution). Alternatively, samples were analyzed using antibodies against Hsc70 (Abcam ab51052; 1:5000), Apg2 (Abcam ab185962; 1:5000) and DnaJB1 (Enzo ADI-SPA-450, 1:2000). 4.4. Disaggregation

(11) Merkel cell polyomavirus T-antigens regulate DICER1 mRNA stability and translation through HSC70iScienceNovember 19, 2021Gao J, Shi H, Juhlin CC, Larsson C, Lui WO.different HSC70 antibodies (sc-7298 from Santa Cruz Biotechnology, NBP2-67335 from Novus Biologicals and ab51052 from Abcam). Unfortunately, none of these antibodies could pull down the HSC70 complexes (data not shown),

(12) An Autophagy Modulator Peptide Prevents Lung Function Decrease and Corrects Established Inflammation in Murine Models of Airway AllergyCellsSeptember 18, 2021François Daubeuf, Nicolas Schall, Nathalie Petit-Demoulière, Nelly Frossard, Sylviane Muller12994S), lysosome-associated membrane protein type 2A (LAMP2A; Abcam, ab125068), and HSPA8 (Abcam, ab51052). The secondary antibodies were HRP-conjugated goat anti-mouse or anti-rabbit IgG antibody (Jackson

(13) Moderate Ethanol Pre-treatment Mitigates ICH-Induced Injury via ER Stress Modulation in RatsFrontiers in Molecular NeuroscienceJune 25, 2021Peter Bor-Chian Lin, Po-Kai Wang, Cheng-Yoong Pang, Wei-Fen Hu, Andy Po-Yi Tsai, Adrian L. Oblak, Hock-Kean LiewCell Signaling Technology, Inc., Beverly, MA; 1–1,000), GRP94 (Cat. ab13509, Abcam; 1–2,000), Hsc70 (Cat. ab51052, Abcam; 1–2,000), CCAAT-enhancer-binding protein homologous protein (CHOP) (2895; Cell Signaling Technology,

(14) Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating SynteninJournal of extracellular vesiclesMarch 1, 2021Zhang Y, Li Y, Liu P, Gong D, Zhou H, Li W, Zhang H, Zheng W, Xu J, Cheng H, et al.(ab131541), Syntenin (ab133267, ab19903), CD9 (ab92726), ALIX (ab186429), TSG101 (ab125011), HSC70 (ab51052), Annxein A1 (ab214486), Syndecan‐1 (ab128936), GM130 (ab187514), Calnexin (ab22595), GRP94 (ab238126),

(15) Single‐step equipment‐free extracellular vesicle concentration using super absorbent polymer beadsJournal of Extracellular VesiclesFebruary 23, 2021Hee Cheol Yang, Yoo Min Ham, Jeong Ah Kim, Won Jong RheeMEX002‐3, USA) at 1:1000, rabbit anti‐Syntenin (Abcam, ab133267, UK) at 1:2000, rabbit anti‐Hsc70 (Abcam, ab51052, UK) at 1:500, rabbit anti‐GM130 (Abcam, ab52649, UK) at 1:1000, rabbit anti‐Calnexin (Cell Signaling Technology

(16) Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic ReticulumNeuronJanuary 20, 2021Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V.RRID:AB_10015242" Homer1 (rabbit),Synaptic Systems,"Cat# 160 003, RRID:AB_887730" HSC70 (rabbit),Abcam,"Cat# ab51052, RRID:AB_880538" IP3R1 (rabbit),Cell Signaling Technology,"Cat# 8568, RRID:AB_10890699" IP3R3 (rabbit),Millipore,"Cat#

(17) Single Step In Situ Detection of Surface Protein and MicroRNA in Clustered Extracellular Vesicles Using Flow CytometryJournal of Clinical MedicineJanuary 17, 2021Hee Cheol Yang, Won Jong Rheedilution, rabbit anti-Syntenin (Abcam, ab133267, Cambridge, UK) at 1:2000, rabbit anti-Hsc70 (Abcam, ab51052, Cambridge, UK) at 1:500, rabbit anti-GM130 (Abcam, ab52649, Cambridge, UK) at 1:1000, and rabbit anti-calnexin

(18) The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregatesThe Journal of biological chemistryJanuary 1, 2021Mukherjee T, Ramaglia V, Abdel-Nour M, Bianchi AA, Tsalikis J, Chau HN, Kalia SK, Kalia LV, Chen JJ, Arnoult D, et al.LC3-A/B (#4108, Cell Signaling Technology), rabbit anti-GFP (#ab290, Abcam, 1:5000), rabbit anti-Hsc70 (#ab51052, Abcam, 1:1000), mouse anti-α-synuclein (#ab1903, Abcam 1/3000), rabbit anti-α-synuclein phospho-S129

(19) Clinical Implications of HSC70 Expression in Clear Cell Renal Cell CarcinomaInternational Journal of Medical SciencesJanuary 1, 2021Yixiao Zhang, Xudong Zhu, Xinbo Qiao, Lisha Sun, Tianhui Xia, Caigang Liuwere incubated overnight at 4 °C with a primary antibody against HSC70 (1:50) purchased from Abcam (ab51052). After washing, cells probed with the primary HSC70 antibody were detected by incubating with horseradish

(20) In Vivo Remodeling of Altered Autophagy-Lysosomal Pathway by a Phosphopeptide in LupusCellsOctober 20, 2020Wang F, Tasset I, Cuervo AM, Muller S.The sources of antibodies used in this study were—LAMP2A (ab125068), LAMP1, GAPDH (ab9482), HSPA8 (ab51052), HSP90 (ab203126), Tomm20 (ab209951), all from Abcam (Cambridge, England), GBA (PA5-52319, ThermoFisher Scientific

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Anti-Hsc70 antibody [EP1531Y] from Abcam

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Anti-Hsc70 antibody [EP1531Y] from Abcam

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