alpha-Tubulin (11H10) Rabbit mAb 2125S from Cell Signaling Technology

Product Specs
Itemalpha-Tubulin (11H10) Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2125S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-IC, FC-FP
ReactivityH, M, R, Mk, Dm, Z, B, Pg
Targettubulin alpha
HostRabbit
NCBI Gene AliasesK-ALPHA-1
ClonalityMonoclonal
NCBI Full Gene Nametubulin alpha 1b
Research AreaCytoskeletal Signaling
IsotypeIgG
Clone11H10
Molecular Weight52

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Mitochondrial phosphoproteomes are functionally specialized across tissuesLife Science AllianceFebruary 1, 2024Fynn M Hansen, Laura S Kremer, Ozge Karayel, Isabell Bludau, Nils-Göran Larsson, Inge Kühl, Matthias MannGADPH (GTX627408; GeneTex), PDI (GTX30716; GeneTex), TFAM (ab131607; Abcam), tubulin (clone 11H10, 2125; Cell Signaling), VDAC1 (clone N152B/23, MABN504; Millipore). Mitochondrial (phospho)proteome sample

(2) Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluationJournal of Enzyme Inhibition and Medicinal ChemistryDecember 31, 2023Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wangincubated for additional 24 h. Colchicine was used as the positive control. Anti-α-tubulin antibody (CST, #2125) and Alexa Fluor 594 donkey anti-rabbit IgG (Yeasen, 34212ES60) were used to visualise the microtubules.

(3) Severe pneumonia and pathogenic damage in human airway epithelium caused by Coxsackievirus B4Emerging Microbes & InfectionsDecember 8, 2023Jing Dai, Duo Xu, Chao Yang, Huan Wang, Dehui Chen, Zhengshi Lin, Shuyan Qiu, Li Zhang, Xiao Li, Xingui Tian, et al.primary CVB4 – (#MAB941, Merck, USA), ZO-1 – (#13663, CST, Danvers, MA, USA), and α-tubulin-specific (#2125, CST, USA) antibodies diluted 1:200 to 1:1000 in PBS plus 2% goat serum, according to the suppliers

(4) Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinomaJournal of enzyme inhibition and medicinal chemistryDecember 1, 2023He F, Chen J, Zhao T, Wu Q, Yin N, Wang X, Zhong Y, Guo X, Qiu Y, Li B, et al.Proteintech), anti-LC3 (#14600–1-AP, Proteintech), anti-Cleaved PARP (#A19612, Abclonal), anti-α-tubulin (#2125, Cell Signalling Technology), anti-Lamin B1 (#A11495, Abclonal), anti-Nur77 (#3960, Cell Signalling

(5) Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemiasScience AdvancesDecember 1, 2023Yuki Nishida, Jo Ishizawa, Edward Ayoub, Rafael Heinz Montoya, Lauren B. Ostermann, Muharrem Muftuoglu, Vivian R Ruvolo, Tallie Patsilevas, Darah A. Scruggs, Shayaun Khazaei, et al.#9715), MCL1 (D35A5; Cell Signaling Technology, #5453), α-tubulin (11H10; Cell Signaling Technology, #2125), p21 (12D1; Cell Signaling Technology, #2947). Nuclear and cytoplasmic proteins were extracted using

(6) An adaptive stress response that confers cellular resilience to decreased ubiquitinationNature CommunicationsNovember 14, 2023Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, et al.#4561096), followed by probing with anti-FLAG (Cell Signaling #14793) and anti-α-tubulin (Cell Signaling #2125) antibodies at 1:1000. Western blots of detergent-soluble and insoluble protein fractions from HEK293T

(7) Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory BalanceASN NeuroNovember 1, 2023Cai-Yan Xue, Tian Gao, E Mao, Zhen-Zhen Kou, Ling Dong, Feng Gaoprimary antibodies at 4 °C: rabbit anti α-Tubulin (11H10) antibody (Cell Signaling Technology Cat# 2125, RRID:AB_2619646, Cell Signaling Technology, USA, 1:1000), rabbit anti InsRβ (4B8) antibody (Cell Signaling Technology

(8) Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulatorsNature CommunicationsOctober 23, 2023Qiaoqiao Zhang, Kai Deng, Mengyou Liu, Shengye Yang, Wei Xu, Tong Feng, Minwen Jie, Zhiming Liu, Xiao Sheng, Haiyang Chen, et al.include anti-BuGZ (rabbit, 1:1000), anti-α-tubulin (rabbit, 1:2000, Cell Signaling Technology, Cat# 2125), anti-YT521-B (rabbit, 1:1000). Secondary antibodies were horseradish peroxidase-conjugated goat anti-mouse

(9) Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa CellsAntioxidants (Basel)October 19, 2023Xuan Zhang, Dingding Zhang, Hongmin Li, Zhaojun Liu, Yatong Yang, Jiameng Li, Lishiyuan Tang, Jingli Tao, Honglin Liu, Ming ShenProteintech, 50599-2-Ig), BCL2 (1:1000, Proteintech, 68103-1-Ig), TUBA1A (1:2000, Cell Signaling Technology, 2125), Anti-Rabbit IgG H&L (HRP), 1:2000, Abcam, Cambridge, UK, ab6721; Goat Anti-Mouse IgG H&L (HRP), 1:2000,

(10) Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicityCell Communication and SignalingSeptember 25, 2023Bhavneet Kaur, Pradeep Kumar Sharma, Barun Chatterjee, Bhawana Bissa, Vasugi Nattarayan, Soundhar Ramasamy, Ajay Bhat, Megha Lal, Sarbani Samaddar, Sourav Banerjee, et al.BMLPW8810, 1:1000), anti-GAPDH (CST 5174, 1:2000), anti-Actin (BD 612657, 1:2000), anti-⍺-Tubulin (CST 2125, 1:2000), anti-Phospho-mTOR (CST 2974, 1:1000), anti-mTOR (CST 2983, 1:1000), anti-Phospho-p70 S6K (CST

(11) Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheresFrontiers in PharmacologySeptember 19, 2023Shaomin Wang, Liang Wang, Qian Bu, Qian Wei, Linhong Jiang, Yanping Dai, Ni Zhang, Weihong Kuang, Yinglan Zhao, Xiaobo CenAbcam), mouse anti-Cyclin A (1:500; sc-271645; Santa Cruz Biotechnology), rabbit anti-ɑ-Tubulin (1:2000; #2125; Cell Signaling Technology). 2.10 Cell cycle assay Neurospheres were dissociated into single cells

(12) GPER1 Activation Exerts Anti-Tumor Activity in Multiple MyelomaCellsSeptember 7, 2023Maria Eugenia Gallo Cantafio, Roberta Torcasio, Francesca Scionti, Maria Mesuraca, Domenica Ronchetti, Mariaelena Pistoni, Dina Bellizzi, Giuseppe Passarino, Eugenio Morelli, Antonino Neri, et al.(#12827P), PARP (#9532), Sp1 (#9389S), MCL-1 (#5453S), CDK6 (#13331), GAPDH (#5174), and α-tubulin (#2125S), all purchased from Cell Signaling Technology; or GPER1 (ab154069) from Abcam (Cambridge, UK). 2.9.

(13) Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cellsCellular and Molecular Life SciencesSeptember 5, 2023Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerdenserum albumin (BSA) for 30 min at RT. Cells were incubated with α-tubulin antibody (Cell signaling #2125, Leiden, The Netherlands) or with a-RhoA (NewEast Biosciences; #26,904) at a dilution of 1:100 in PBS

(14) Targeting phosphomevalonate kinase enhances radiosensitivity via ubiquitination of the replication protein A1 in lung cancer cellsCancer scienceSeptember 1, 2023Park SS, Kwon MR, Ju EJ, Shin SH, Park J, Ko EJ, Son GW, Lee HW, Kim YJ, Moon GJ, et al.(HPA029900), MRE11(HPA002691) and RPA1 (HPA006914) were obtained from Atlas Antibodies. Alpha‐tubulin (#2125) and cleaved caspase‐3 (#9661) antibodies were purchased from Cell Signaling Technology. Anti‐beta‐actin

(15) ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumorsCancer Cell InternationalAugust 18, 2023Seol Hwa Shin, Eun Jin Ju, Jin Park, Eun Jung Ko, Mi Ri Kwon, Hye Won Lee, Ga Won Son, Yun-Yong Park, Yeon Joo Kim, Si Yeol Song, et al.MD). Antibodies Antibodies to detect B7-H3 (ab134161) and PARP-1(ab32071) were from Abcam. Alpha-tubulin (#2125), cyclin A (#4656), p-Chk1 (#2341), and Chk1 (#2345) antibodies were bought from Cell Signaling Technology.

(16) UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryosLife science allianceAugust 1, 2023Uemura S, Maenohara S, Inoue K, Ogonuki N, Matoba S, Ogura A, Kurumizaka M, Yamagata K, Sharif J, Koseki H, et al.PBS and then fixed with 4% PFA. The cells were incubated with the antibody against α-tubulin (1:200, 2125; Cell Signaling Technology) at 4°C overnight. After washing several times, the cells were incubated

(17) Androgen receptor transcriptional activity is required for heregulin-1β–mediated nuclear localization of the HER3/ErbB3 receptor tyrosine kinaseJournal of Biological ChemistryAugust 1, 2023Maitreyee K. Jathal, Salma Siddiqui, Demitria M. Vasilatis, Blythe P. Durbin Johnson, Christiana Drake, Benjamin A. Mooso, Leandro S. D’Abronzo, Neelu Batra, Maria Mudryj, Paramita M. Ghoshanti-ErbB3 (CS-12708), phospho-ErbB3(Y1289), AR (CS-3202 and CS-5153), Lamin A/C (CS-2032), α-tubulin (CS-2125), pAKT (CS-4060), and pERK (CS-9101 were from Cell Signaling Technology. Rabbit polyclonal anti-ErbB3

(18) Lnc-PXMP4-2-4 alleviates myocardial cell damage by activating the JAK2/STAT3 signaling pathwayHeliyonAugust 1, 2023Hong Zhang, Qinlin Guo, Guiju Feng, Xin Shen, Xinxin Feng, Yi Guo, Shouyan Wang, Xia Zhong(Bcl-2,ab194583; Bax,ab182733; JAK2,ab32101; STAT3,ab109085) or α-Tublin primary antibody (1:2000; 2125S, CST), etc. were treated overnight at 4 °C and then associated with secondary antibodies (1:2000; Santa

(19) Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenomeeLifeJuly 20, 2023Shin H, Leung A, Costello KR, Senapati P, Kato H, Moore RE, Lee M, Lin D, Tang X, Pirrotte P, et al.8457,WB (1:1000) Antibody,Anti-alpha-tubulin (11H10)(rabbit monoclonal),Cell Signaling Technology,Cat# 2125,WB (1:1000) Antibody,Anti-DNMT1 (60B1220.1)(mouse monoclonal),Novus Biologicals,Cat# NB100-56519,IP

(20) Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposonsNature communicationsJuly 15, 2023Liu Y, Hu L, Wu Z, Yuan K, Hong G, Lian Z, Feng J, Li N, Li D, Wong J, et al.anti-p-IRF3 (#4947, 1:1000), anti-IRF3 (#4302, 1:1000), anti-SUV39H1 (#8729, 1:1000), anti-ɑ-Tubulin (#2125, 1:1000), anti-Lamin A/C (#4777, 1:1,000), anti-p-STAT1 (#9167, 1:1000) and anti-STAT1 (#9172, 1:1000)

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(1)

8/13/2023Reliable Alpha-Tubulin Antibody From CST Dan ZhaoI used this antibody for my Western blots and used it to detect the expression of internal control alpha-tubulin. It gave me a very clear band in cancer cell lines used.
(1)

10/1/2018Excellent Antibody for Western BlotDr. Raghavendra VadlaWe examined the levels of tubulin in HeLa whole cell lysates of control vs siRNA-mediated knockdown of protein X.

alpha-Tubulin (11H10) Rabbit mAb

alpha-Tubulin (11H10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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alpha-Tubulin (11H10) Rabbit mAb from Cell Signaling Technology

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