Fig 1: Other indicators of cholinergic signaling in bladder cancer. Differences in proportions of urothelial cells positive for (A) M1R (P=0.010), (B) M4R (P=0.010), (C) ChAT (P=0.033) and (D) MMP-9 (P=0.009) between bladder cancer tissue and adjacent tissue. MMP-9, matrix metalloproteinase-9; ChAT, Choline acetyltransferase; M1R, muscarinic cholinergic receptor 1; M4R, muscarinic cholinergic receptor 4.