Fig 1: Corin/PCSK6 staining in the heart chambers of ACF and sham-operated rats. Representative images of immunofluorescence staining for corin (A) and PCSK6 (B) in the cardiac atrial and ventricular tissues of rats with compensated CHF, decompensated CHF, and sham-operated animals. Tissues were counterstained with DAPI. All images were obtained at x40 magnification.
Fig 2: Levels and expression of corin and PCSK6 in the cardiac tissue of compensated CHF, decompensated CHF, and sham controls. Representative western blot analysis of corin and PCSK6 in RA, LA, RV, and LV tissue lysates are shown in (A,B,K,L), respectively. (C–F,M–P) Represent western blot analysis relative quantification of corin and PCSK6 in the different heart chambers, where GAPDH was used as a loading control. Quantification of qPCR analysis for corin and PCSK6 mRNA normalized to GAPDH are depicted in (G–J,Q–T). Values are means ± SEM.
Fig 3: Natriuretic peptide machinery system in the renal tissue of ACF and sham-operated rats. Representative western blot analysis (A) with antibodies against corin, PCSK6, ADAM10, and NEP and their quantification relative to GAPDH (B–E) in the kidney of ACF rats and their sham operated rats. (F–I) represents quantification of qPCR analysis of the mRNA of these enzymes relative to GAPDH. (J) Representative images of immunostaining of corin and PCSK6 in the kidney of the various animal groups, counterstained with DAPI. All images were obtained at x40 magnification. Values are presented as means ± SEM.
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