Integrin alpha4 (D2E1) XP ® Rabbit mAb 8440S from Cell Signaling Technology

Product Specs
ItemIntegrin alpha4 (D2E1) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number8440S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, M, R
ClonalityMonoclonal
TargetIntegrin Alpha 4
HostRabbit
NCBI Full Gene Nameintegrin subunit alpha 4
NCBI Gene AliasesCD49D, IA4
Research AreaAdhesion/ECM
CloneD2E1
Molecular Weight70, 140, 150

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myelomaCell reports. MedicineJuly 18, 2023Di Meo F, Iyer A, Akama K, Cheng R, Yu C, Cesarano A, Kurihara N, Tenshin H, Aljoufi A, Marino S, et al.source,MBS9213625 CD37,Abcam,RRID:AB_1658390 DAGLB,Bethyl,RRID:AB_2632224 FCRL3,Invitrogen,RRID:AB_2804496 IFNGR1,Abcam,RRID:AB_10999916 IL12RB1,Lsbio,RRID:AB_10832104 IL27RA,Cusabio,PA761488ESR1HU IL2RG,Abcam,RRID:AB_2264646 IL6R α,RD systems,MAB227-SP ITGa4,Cellsignaling,8440T ITGB7,Santacruz,RRID:AB_2249383 ITM2C,RD systems,RRID:AB_1964638 KCNA3,Prosci,57–918 KCNN4,Abcam,RRID:AB_1523850 LAX1,Proteintech,RRID:AB_10732821 LILRB1,Abcam,RRID:AB_2296996 LILRB4

(2) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1Frontiers in Cell and Developmental BiologyJune 13, 2023Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, et al.United States), IF: 1:500GFP, 632592 (Clontech, Danvers, MA, United States), IF: 1:500Integrin α4, 8440 (Cell Signaling, Danvers, MA, United States), WB: 1:1,000Integrin β1, 610467 (BD, Franklin Lakes, NJ,

(3) Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's DiseaseAdvanced ScienceMay 18, 2023Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen LiCell Signaling Technology), anti‐VCAM‐1 (1:1000, Cat. no. AF1021, Beyotime), anti‐Integrin α4 (1:1000, Cat. no. 8440, Cell Signaling Technology), anti‐Integrin β1 (1:1000, Cat. no. 9699, Cell Signaling Technology), anti‐β‐actin

(4) The main e-cigarette component vegetable glycerin enhances neutrophil migration and fibrosis in endotoxin-induced lung injury via p38 MAPK activationRespiratory researchJanuary 10, 2023Su VY, Chen WC, Yu WK, Wu HH, Chen H, Yang KY.LifeSpan Biosciences, Seattle, WA), MPO (SC-52707, 1:100, Santa Cruz Biotechnology, Dallas, TX), VLA-4 (#8440S, 1:1000; Cell Signaling, Danvers, MA), VCAM-1 (#14694, 1:1000; Cell Signaling), and TGF-β (ab66043,

(5) Glycan Epitope and Integrin Expression Dynamics Characterize Neural Crest Epithelial-to-Mesenchymal Transition (EMT) in Human Pluripotent Stem Cell DifferentiationStem Cell Reviews and ReportsDecember 1, 2022Ria Thomas, Vishal Menon, Rakesh Mani, Jan PruszakPharmingen,Rat,"552,828",,1:200 CD44 FITC,E Bioscience,Rat,11-044186,1:50, CD49d,Cell Signaling,Rabbit,8440,,1:1000 Doublecortin,Santa Cruz,Goat,sc-8066,1:200,1:500 HNK1,Santa Cruz,Mouse,"sc-81,633",,1:200 HNK1/CD57,BD

(6) In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitisNature communicationsSeptember 28, 2022Zhou X, Yu M, Ma L, Fu J, Guo J, Lei J, Fu Z, Fu Y, Zhang Q, Zhang CY, et al.ab183218, Cambridge, UK), B7-1 (Abcam, ab254579, Cambridge, UK), integrin α4 (Cell Signalling Technology, 8440S, Danvers, MA, USA), F4/80 (Abcam, ab60343, Cambridge, UK) or CD4 (Proteintech, CL488-65141) antibodies

(7) ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migrationJournal of cell scienceFebruary 15, 2022Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A.F1804), anti-GFP (1:1000, Clontech, #632381), anti-integrin-α4 (1:1000, Cell Signaling Technology, 8440T), anti-integrin-α5 (1:1000, Cell Signaling Technology, 4705T), anti-integrin-αV (1:1000, Cell Signaling Technology

(8) DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivoNature communicationsDecember 22, 2021Ohyagi M, Nagata T, Ihara K, Yoshida-Tanaka K, Nishi R, Miyata H, Abe A, Mabuchi Y, Akazawa C, Yokota T.followed by incubation with the primary antibodies against Integrin α4 (Cell Signaling, clone D2E1, #8440), STAT3 (Cell Signaling, clone 124H6, #9139) or peroxidase-conjugated GAPDH (Wako, clone 5A12, #015-25473)

(9) Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung InjuryInternational journal of molecular sciencesSeptember 13, 2021Su VY, Chen WC, Yu WK, Wu HH, Chen H, Yang KY.G6D (Ly6G; LS-C36561, 1:100; LifeSpan Biosciences, Seattle, WA, USA), very late antigen 4 (VLA-4; #8440S, 1:1000; Cell Signaling, Danvers, MA, USA), vascular cell adhesion molecule 1 (VCAM-1; #14694, 1:1000;

(10) Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activityCancer cellAugust 9, 2021Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, et al.,Cell Signaling Technology,Cat# 14803; RRID: AB_2798620 Rabbit monoclonal anti-ITGA4 (clone D2E1),Cell Signaling Technology,Cat# 8440; RRID: AB_2797643 Rabbit polyclonal anti-ITGAV (clone D2E5),Cell Signaling Technology,Cat# 4711; RRID:

(11) ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosisRegenerative BiomaterialsJuly 18, 2021Dan Tang, Yi Wang, Andy Wijaya, Boyan Liu, Ali Maruf, Jinxuan Wang, Jianxiong Xu, Xiaoling Liao, Wei Wu, Guixue Wangmembranes were blocked in 5% milk for 1 h before incubating with primary antibody (anti-integrin α4 (8440S, CST); anti-integrin β1 (34971, CST); anti-CD47 antibody (ab175388, Abcam)) at 4°C overnight. Afterwards,

(12) Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expressionWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyJuly 1, 2021Zheng R, Varney SD, Wu L, DiPersio CM, Van De Water L.13778–75), and GAPDH antibody (# AM4300) are from ThermoFisher Scientific; Cox-2 (# 12282), integrin α4 (# 8440), and phospho-NF-ĸB p65 (# 3033) antibodies are from Cell Signaling; Nrf2 antibody (# ab2352) are from

(13) Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injuryTheranosticsJanuary 1, 2021Cao JY, Wang B, Tang TT, Wen Y, Li ZL, Feng ST, Wu M, Liu D, Yin D, Ma KL, et al.Invitrogen), anti-VCAM-1 (39036, Cell Signaling Technology), anti-LFA-1 (ab13219, Abcam), anti-integrin α4 (8440, Cell Signaling Technology), anti-integrin β1 (sc-374429, Santa Cruz), anti-PCNA (sc-56, Santa Cruz),

(14) Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applicationsTheranosticsJanuary 1, 2021Yi Wang et al.(Millipore, USA). Then, the membranes were treated with primary antibodies against α4 (anti-integrin α4, 8440S, CST), β1 (anti-integrin β1, 34971, CST), and CD47 (anti-CD47 antibody, ab175388, Abcam), followed by

(15) Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKIScience advancesAugust 1, 2020Tang TT, Wang B, Wu M, Li ZL, Feng Y, Cao JY, Yin D, Liu H, Tang RN, Crowley SD, et al.anti-CD206 (ab64693, Abcam), anti–IL-10 (ab9969, Abcam), anti–IL-10R (ab225820, Abcam), anti–integrin α4 (8440, Cell Signaling Technology), anti–integrin α5 (98204, Cell Signaling Technology), anti–integrin αL (ab186873,

(16) Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C ExpressionInvestigative Opthalmology & Visual ScienceFebruary 13, 2020Emil Carlsson, Wasu Supharattanasitthi, Malcolm Jackson, Luminita ParaoanCell Signaling Technology), ZO2 (2847; Cell Signaling Technology), claudin-3 (214487; Abcam), integrin α4 (8440; Cell Signaling Technology) and integrin β1 (9699; Cell Signaling Technology). Proteins were finally

(17) Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotidesScientific reportsSeptember 10, 2019Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD.Acetone:MetOH (1:1) for 5 min before incubation with primary antibody (Cell Signaling Technology, cat. no. 8440) diluted in TBST with 1% goat serum at 1:200 for 1 h at room temperature. The coverslips were then washed

(18) Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and FibrosisTheranosticsJuly 9, 2019Tao-Tao Tang et al.Abcam); anti-CD206 (ab64693, Abcam); anti-actinin 4 (15145, Cell Signaling Technology); anti-integrin α4 (8440, Cell Signaling Technology); anti-integrin β1 (4706, Cell Signaling Technology); anti-integrin αL (ab186873,

(19) Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruseseLifeFebruary 25, 2019Rivera-Serrano EE, González-López O, Das A, Lemon SM.(Abcam, ab133557, 1:500), anti-integrin α3 (Millipore, AB1920, 1:250), anti-integrin α4 (Cell Signaling, 8440, 1:250), anti-integrin α5 (Cell Signaling, 4705, 1:700), anti-integrin αV (Cell Signaling, 4711, 1:700).

(20) Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γPLOS GeneticsNovember 19, 2018Colby L. Samstag, Jake G. Hoekstra, Chiu-Hui Huang, Mark J. Chaisson, Richard J. Youle, Scott R. Kennedy, Leo J. Pallanck

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Integrin alpha4 (D2E1) XP ® Rabbit mAb

Integrin alpha4 (D2E1) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (28)

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Integrin alpha4 (D2E1) XP ® Rabbit mAb from Cell Signaling Technology

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