Anti-Cortactin antibody [4F11] ab33333 from Abcam

Product Specs
ItemAnti-Cortactin antibody [4F11]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab33333
Antibody TypePrimary
ClonalityMonoclonal
Clone4F11
ApplicationsImmunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
HostMouse, Nude mouse
IsotypeIgG1
Quantity100 UG
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NameCTTN
ValidationKnockOut Validated
ReactivityCow, Human, Mouse, Rat
TargetCortactin

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Invadopodia enable cooperative invasion and metastasis of breast cancer cellsCommunications BiologyDecember 1, 2022Louisiane Perrin, Elizaveta Belova, Battuya Bayarmagnai, Erkan Tüzel, Bojana Gligorijevicincubated with anti-β-actin (Santa Cruz Biotechnology, sc-47778; 1 to 500), anti-cortactin (Abcam, ab33333; 1 to 1000), anti-E-cadherin (BD Transduction Laboratories, 610181; 1 to 1000), anti-FAK (Santa Cruz Biotechnology

(2) Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actinJournal of cell scienceAugust 15, 2022Gao N, Raduka A, Rezaee F.antibodies against the following proteins were used: cortactin (05-180, Millipore Sigma, Darmstadt, Germany; ab33333, Abcam, Cambridge, UK), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (ab8245, Abcam), pan-actin

(3) YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancerOncogeneJuly 29, 2022Jie Shen, Qingwen Huang, Weiyi Jia, Shengjie Feng, Liang Liu, Xiaolan Li, Deding Tao, Daxing Xiedewaxed, rehydrated, and incubated with 1:100 diluted TKS5 (Cat.# A9363, Abclonal, China) /cortactin (Cat.#ab33333, Abcam, UK) antibodies for 2 h at 25 °C after heat-induced epitope retrieval. Cy3- and Alexa Fluor 488

(4) Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylationInternational journal of biological sciencesJanuary 1, 2022Li F, Wu X, Fu X, Liu J, Song W, Xiao GG, Lu A, Zhang G.anti-Poly (ADP-Ribose) polymer polyclonal antibody (Abcam, ab14460), Anti-Cortactin antibody [4F11] (Abcam, ab33333), E-cadherin polyclonal antibody (Proteintech, 20874-1-AP), fibronectin polyclonal antibody (Proteintech,

(5) Estrogen Receptor Beta Prevents Signet Ring Cell Gastric Carcinoma Progression in Young Patients by Inhibiting Pseudopodia Formation via the mTOR–Arpc1b/EVL Signaling PathwayFrontiers in Cell and Developmental BiologyJanuary 21, 2021Xingzhou Wang, Xuefeng Xia, En Xu, Zhi Yang, Xiaofei Shen, Shangce Du, Xiaotong Chen, Xiaofeng Lu, Wei Jin, Wenxian GuanCell Signaling Technology, United States), mTOR (2983T, Cell Signaling Technology), ERβ (ab3576, Abcam), and cortactin (ab33333, Abcam). The secondary antibodies were horseradish peroxidase (HRP)-linked anti-rabbit immunoglobulin

(6) Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate CortactinInternational Journal of Molecular SciencesDecember 25, 2020Carole Luthold, Alice-Anaïs Varlet, Herman Lambert, François Bordeleau, Josée N. Lavoieanti-Flag M2 (F3165, 1/200) and anti-α-tubulin mouse (T5168, 1:10000; Sigma-Aldrich); anti-cortactin (ab33333, 1:1000) and anti-α-tubulin rabbit (ab18251, 1:1000; Abcam); anti-acetyl-cortactin K309 (ABT1378, 1:1000);

(7) piR-19166 inhibits migration and metastasis through CTTN/MMPs pathway in prostate carcinomaAging (Albany NY)September 3, 2020Tingyue Qi, Haiyan Cao, Hongguang Sun, Hao Feng, Nianfeng Li, Chenghai Wang, Lei Wangwas performed as previously described [12]. The primary antibodies were as follows: anti- CTTN (Cat # ab33333, Abcam), and anti- MT1-MMP (Cat #ab3644, Abcam); anti-MMP2 (Cat #97779, Abcam), anti- MMP9 (Cat # ab38898,

(8) Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cellsMatrix BiologyJanuary 1, 2020Katrina M. Wisdom, Dhiraj Indana, Pei-En Chou, Rajiv Desai, Taeyoon Kim, Ovijit Chaudhuriantibody (1:300; Abcam, Y113), Anti-β1 Integrin (1:300; Abcam, P5D2), and Anti-Cortactin (1:300; Abcam, ab33333). Negative controls, where the secondary antibody was added but the primary antibody was not, were conducted

(9) EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signalingJCI InsightDecember 5, 2019Shinya Sato, Suhas Vasaikar, Adel Eskaros, Young Kim, James S. Lewis, Bing Zhang, Andries Zijlstra, Alissa M. WeaverARTICLE (EPR10072[B], ab150411, mouse monoclonal), CD31 (EPR3094, ab76533, rabbit monoclonal), and cortactin (4F11, ab33333, mouse monoclonal) were purchased from Abcam. EPHB2 (AF467, goat polyclonal) and goat IgG HRP conjugated antibody

(10) Optogenetic control of cofilin and αTAT in living cells using Z-lockNature Chemical BiologyDecember 1, 2019Orrin J. Stone et al.β-Actin (8H10D10) Mouse mAb (Cell Signaling #3700), Tks5 (Santa Cruz Biotechnology; sc-30122), Cortactin (Abcam; ab33333). The cDNA of the LOV2 domain from Avena sativa (oat) Phototropin1 (L404-L547) was used to generate

(11) The Role of PAK1 in the Maturation of Invadopodia During Transient Mechanical StimulationFrontiers in Cell and Developmental BiologyNovember 6, 2019Alexander N. Gasparski, Jacob T. Wilson, Anindita Banerjee, Karen A. Beningousing 5% BSA (Santa Cruz) in 1x PBS overnight at 4°C. A mouse monoclonal anti-cortactin (1:500, cat# ab33333, Abcam) antibody was prepared in blocking solution overnight at 4°C. Samples were then incubated with

(12) Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent MannerMolecular cancer research : MCRMay 1, 2019Valenzuela-Iglesias A, Burks HE, Arnette CR, Yalamanchili A, Nekrasova O, Godsel LM, Green KJ.BioResearch, Columbia, MO). Antibodies The following primary antibodies were used: the cortactin antibody (ab33333) was from Abcam. The GAPDH (sc-365062) antibody was from Santa Cruz Biotechnology, Inc. The Tks5 (sc-30122)

(13) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironmentsNature communicationsOctober 8, 2018Wisdom KM, Adebowale K, Chang J, Lee JY, Nam S, Desai R, Rossen NS, Rafat M, West RB, Hodgson L, et al.Tris base, 0.1% Tween, pH 7.4), incubated overnight in primary antibodies against CTTN (1:1000; cat. #ab33333; Abcam) and SH3PXD2A (1:200; cat. #sc-376211; Santa Cruz Biotechnology), and p38 (1:2000; cat. #sc-535;

(14) A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular DegenerationInvestigative ophthalmology & visual scienceMarch 20, 2018Ghosh S, Shang P, Terasaki H, Stepicheva N, Hose S, Yazdankhah M, Weiss J, Sakamoto T, Bhutto IA, Xia S, et al.MA5-11883; Thermo Fisher Scientific, Waltham, MA, USA), β-Catenin (Cat# ab16051; Abcam), Cortactin (Cat# ab33333; Abcam), phospho(Y421)-cortactin (Cat# 4569S; Cell Signaling Technology, Danvers, MA, USA), Snail1 (Cat#

(15) Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradationJournal of Cell BiologyDecember 4, 2017Sara K. Donnelly, Ramon Cabrera, Serena P.H. Mao, John R. Christin, Bin Wu, Wenjun Guo, Jose Javier Bravo-Cordero, John S. Condeelis, Jeffrey E. Segall, Louis Hodgsontransfected cells was quantified. Invadopodia were identified by costaining with Cortactin (mouse; ab33333; Abcam) and Tks5 (rabbit; M-300 [Santa Cruz Biotechnology, Inc.] or 09-403 [EMD Millipore]) antibodies

(16) The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasionOncogeneNovember 9, 2017Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, et al.control were obtained from R&D systems (Minneapolis, MN, USA). The mouse monoclonal anti-cortactin (ab33333), function-blocking mouse monoclonal anti-MMP14 (ab78738) and rabbit polyclonal anti-MMP14 (ab51074)

(17) PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3KMolecular CellNovember 2, 2017Mouhannad Malek et al.,Cell Signaling,4267; RRID: AB_2246311 Anti-phospho-EGFR,Cell Signaling,3777; RRID: AB_2096270 Anti-Cortactin,Abcam,Ab33333; RRID: AB_731713 "Biotinylated anti-PI(3,4)P2",Echelon Biosciences,z-B034b; RRID: AB_427214 Alexa

(18) Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitroJournal of cell scienceJune 1, 2017Gasparski AN, Ozarkar S, Beningo KA.solution containing 5% BSA (Fisher) in 1× PBS overnight at 4°C. A mouse monoclonal anti-cortactin (1:500, cat# ab33333, Abcam) was prepared in blocking solution overnight at 4°C. A secondary anti-mouse-IgG conjugated to

(19) Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cellsMolecular biology of the cellMay 15, 2017Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ.(sc-30771), Tks5 (sc-30122), and Arp2 (sc-H-84) antibodies were from Santa Cruz Biotechnology. Cortactin (ab33333) was from Abcam. Anti-actin (Millipore), anti-GFP (Rockland), Rac1/3 (Upstate), specific anti-Rac3 (ProteinTech

(20) The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 DomainFrontiers in Cellular NeuroscienceMay 4, 2017Arlek M. González-Jamett, María J. Guerra, María J. Olivares, Valentina Haro-Acuña, Ximena Baéz-Matus, Jacqueline Vásquez-Navarrete, Fanny Momboisse, Narcisa Martinez-Quiles, Ana M. Cárdenas

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Anti-Cortactin antibody [4F11] from Abcam

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Anti-Cortactin antibody [4F11] from Abcam

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