Fig 1: Proposed model for the acting mechanisms underlying the regulation of mitochondrial energy metabolism of mice by Astragaloside IV (AST). AST exerts its role on metabolic regulation in healthy ageing mice, mainly by activating AMPK, which leads to the inhibition of ACC1 and activation of fatty acid ß-oxidation in mouse liver
Fig 2: Astragaloside IV (AST) increased the levels of phosphorylated AMPK and ACC1 in the liver of ageing mice and reduced the content of malonyl-CoA. (A) Representative Western blot results of AMPK, ACC1, phosphorylated AMPK and ACC1. The histogram shows the ratio of phosphorylated AMPK to AMPK, and the ratio of phosphorylated ACC1 to ACC1. (B) The reduced malonyl-CoA levels caused by AST treatment. The results are expressed as mean ± SD, and statistical significance is indicated as *p < 0.05, **p < 0.01, ***p < 0.001 (n = 10)
Supplier Page from Abcam for Anti-AMPK alpha 2 (phospho S345) antibody [EPMDAR6]