Brilliant Violet 421(TM) anti-human Perforin 353307 from BioLegend

Product Specs
ItemBrilliant Violet 421(TM) anti-human Perforin
CompanyBioLegend
Price Pricing Info Supplier Page View Company Product Page
Catalog Number353307
NCBI Gene AliasesHPLH2, P1, PFP
Conjugate/TagBrilliant Violet 421™
ReactivityHuman
HostMouse
ApplicationsIntracellular Staining for Flow Cytometry (ICFC)
CloneB-D48
IsotypeIgG1
Quantity25 tests
NCBI Full Gene Nameperforin 1
FormatPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Antibody TypePrimary
ClonalityMonoclonal
TargetPerforin

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustionScience translational medicineNovember 9, 2022Jung IY, Narayan V, McDonald S, Rech AJ, Bartoszek R, Hong G, Davis MM, Xu J, Boesteanu AC, Barber-Rotenberg JS, et al.#502534; 3 μL/100 μL), TNF-α-Alexa Fluor700 (BioLegend #502928; 3 μL/100 μL), Perforin-BV421 (BioLegend # 353307; 2 μL/100 μL), Perforin-APC (BioLegend #308112; 2 μL/100 μL), Granzyme B-PE-Cy5.5 (Invitrogen #GRB18;

(2) Soluble trivalent engagers redirect cytolytic T cell activity toward tumor endothelial marker 1Cell reports. MedicineAugust 17, 2021Fierle JK, Brioschi M, de Tiani M, Wetterwald L, Atsaves V, Abram-Saliba J, Petrova TV, Coukos G, Dunn SM.were stained with FITC anti-hCD3 (Biolegend Cat# 317305), BV421 anti-human perforin (Biolegend Cat# 353307) and PE anti-human granzyme B (BD Biosciences Cat# 561142). Antigen binding by CAR-T cells was assessed

(3) MAIT cell activation is associated with disease severity markers in acute hantavirus infectionCell reports. MedicineMarch 16, 2021Maleki KT, Tauriainen J, García M, Kerkman PF, Christ W, Dias J, Wigren Byström J, Leeansyah E, Forsell MN, Ljunggren HG, et al.,BD Biosciences,"Cat#557943, clone UCHT1" Mouse monoclonal anti-perforin BV421 conjugated,BioLegend,"Cat#353307, clone GB11, RRID:" Mouse monoclonal anti-CD8a BV570 conjugated,BioLegend,"Cat#301038, clone RPA-T8,

(4) The Identity of Human Tissue-Emigrant CD8⁺ T CellsCellDecember 23, 2020Buggert M, Vella LA, Nguyen S, Wu VH, Chen Z, Sekine T, Perez-Potti A, Maldini CR, Manne S, Darko S, et al.(RRID:AB_940483) 10F.9G2 (BV785) [anti-PD-L1],BioLegend,124331 (RRID:AB_2629659) B-D48 (BV421) [anti-perforin],BioLegend,353307 (RRID:AB_11149688) B-D48 (PE-Cy7) [anti-perforin],BioLegend,353315 (RRID:AB_2571972) 4B10 (PE-Dazzle

(5) Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical FunctionImmunitySeptember 15, 2020Gruber CN, Calis JJA, Buta S, Evrony G, Martin JC, Uhl SA, Caron R, Jarchin L, Dunkin D, Phelps R, et al.No. 305508; RRID:AB_2133129 Mouse anti-Perforin Briliant Violet 421 Clone B-D48,BioLegend,Cat No. 353307; RRID:AB_ 11149688 Mouse anti-IFN-gamma Alexa Fluor 700 Clone 4S.B3,BioLegend,Cat No. 502520; RRID:AB_528921 Mouse

(6) COVID-19 pneumonia: CD8⁺ T and NK cells are decreased in number but compensatory increased in cytotoxic potentialClinical immunology (Orlando, Fla.)September 1, 2020Jiang Y, Wei X, Guan J, Qin S, Wang Z, Lu H, Qian J, Wu L, Chen Y, Chen Y, et al.

(7) Interferon-α alters host glycosylation machinery during treated HIV infectionEBioMedicineSeptember 1, 2020Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, et al./ThermoFisher Scientific, catalogue# 50–4877–42, RRID:AB_2574229), Perforin (BV421; clone B-D48; Biolegend, catalogue# 353307, RRID:AB_11149688), IFNγ (Alexa Fluor (AF700); clone B27; BD Biosciences, catalogue# 557995, RRID:AB_396977),

(8) Unique T-Cell Populations Define Immune-Inflamed Hepatocellular CarcinomaCellular and molecular gastroenterology and hepatologyJanuary 1, 2020Di Blasi D, Boldanova T, Mori L, Terracciano L, Heim MH, De Libero G.B,FITC,Mouse,Human/mouse,GB11,Biolegend,515403 Perforin,Brilliant Violet 421,Mouse,Human,B-D48,Biolegend,353307 Helios,PE/Cy7,Mouse,Human,22F6,Biolegend,137236 Foxp3,Alexa Fluor 647,Mouse,Human,150D,Biolegend,320014 IL13,PE/Cy7,Mouse,Human,JES10-5A2,Biolegend,501914 GATA-3,Brilliant

(9) Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populationsJournal of hepatologySeptember 1, 2018Hunter S, Willcox CR, Davey MS, Kasatskaya SA, Jeffery HC, Chudakov DM, Oo YH, Willcox BE.

(10) Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individualsScientific reportsJanuary 13, 2017Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, et al.

(11) Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV InfectionPLoS pathogensAugust 1, 2016Demers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, Li CK, Eller LA, Rono K, Maganga L, et al.

(12) Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite ControllersThe Journal of infectious diseasesNovember 1, 2015Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR.

(13) Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 InfectionPLoS pathogensAugust 1, 2015Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley MF, Moll M, Sönnerborg A, Nowak P, Sandberg JK.

(14) T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionPLoS pathogensJuly 1, 2014Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson MA, Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg A, et al.

(15) Epidermal nucleases. II. The multiplicity of ribonucleases in guinea-pig epidermisThe Journal of investigative dermatologyMay 1, 1977S W Melbye, I M Freedberg

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(1)

12/2/2016BV421 Anti-Human Perforin Review Lana JagannathanWe are interested in enhancing the killing capacity of HIV-specific CD8 T cells by activating them via TCR specific MHC-peptide ligands, and co-stimulatory molecules. We use purified CD8 T cells from ... Read Review
(1)

12/1/2016Antibody For Staining Of Newly Formed Perforin Nina FlerinThis antibody was used for intracellular staining of human CD8+ T cells upon 12h stimulation with PMA and ionomycin. The antibody works well.

Brilliant Violet 421(TM) anti-human Perforin from BioLegend

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Brilliant Violet 421(TM) anti-human Perforin from BioLegend

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