The ZEB Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to Zeb1, and ZEB2. This antibody recognizes Human, Mouse, and Rat antigen. The ZEB Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, and Western Blot.
Description
ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin