Fig 1: Effects of YZS on the protein expression levels of UbE1a/b, UbE2a, CHIP, UCH-L1 and 26S proteasome in Alzheimer's disease model rats. (A) Representative western blotting images of UbE1a/b, UbE2a, CHIP, UCH-L1 and 26S proteasome in each group. Semi-quantification of (B) UbE1a/b, (C) UbE2a, (D) CHIP, (E) UCH-L1 and (F) 26S proteasome expression levels in each group. Data are presented as the mean ± SD (rats n=3). #P<0.05, ##P<0.01 vs. Sham group; **P<0.01 vs. Model group. UbE1a/b, ubiquitin-activating enzyme E1a/b; UbE2a, ubiquitin-conjugating enzyme E2a; CHIP, carboxyl terminus of Hsc70-interacting protein; UCH-L1, ubiquitin C-236 terminal hydrolase L1; YZS, Yuan-zhi-san.