Fig 1: LepR fl+/+Cx3cr1 Cre+/- mice have less POMC neurons and less projections from the ARC to PVN. LepR fl+/+Cx3cr1 Cre+/- mice (B1) have a lower POMC cell number compared with WT (A1, C) and a tendency towards increased AGRP-ir (B2) compared with WT (A2, D) in the ARC. Meanwhile, the projections from the ARC to PVN containing a-MSH are decreased in the PVN in LepR fl+/+Cx3cr1 Cre+/- mice (F1) compared with WT (E1, G), while AGRP fiber density were not altered in the PVN (E2, F2, H). Data are presented by Mean ± SEM; **p < 0.01, ***p < 0.001. Scale bar: 100 um. III: Third ventricle. All data presented are from male mice.
Supplier Page from Abcam for Anti-alpha MSH antibody