Fig 1: Effect of tolfenamic acid on genes involved in the p53 pathway in the striatum of the malonic acid-injected rats. There was no significant difference in the mRNA level of Wig1 (A) among all groups. Tolfenamic acid prevented the malonic acid-induced increases in the protein level of Wig1 and the mRNA levels of Mdm2 (B), Pten (C), Puma (D), Bax (E), Sesn2 (F) and Hif-1a (G) and the decrease in Cx3cl1 (H) mRNA levels. However, compared with the malonic acid-injected rats, both doses of tolfenamic acid could not decrease the protein level of Wig1 (I, J). All of the results are expressed as the means ± SEMs. PCR: n = 3; WB: n = 4. #p < 0.05, ##p < 0.01 vs. sham; *p < 0.05, **p < 0.01 vs. MA