APC anti-human CD4 317416 from BioLegend

Product Specs
ItemAPC anti-human CD4
CompanyBioLegend
Price Pricing Info Supplier Page View Company Product Page
Catalog Number317416
NCBI Gene AliasesCD4mut, IMD79, Leu-3, OKT4D, T4
ApplicationsFlow Cytometry (FC)
Conjugate/TagAPC
CloneOKT4
HostMouse
IsotypeIgG2b, Kappa
Quantity100 tests
ReactivityHuman, Cynomolgus, Rhesus
Antibody TypePrimary
NCBI Full Gene NameCD4 molecule
FormatPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
ClonalityMonoclonal
ImmunogenHuman peripheral T cells
TargetCD4

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunityCell ReportsOctober 8, 2023Wenqun Zhong, Youtao Lu, Xuexiang Han, Jingbo Yang, Zhiyuan Qin, Wei Zhang, Ziyan Yu, Bin Wu, Shujing Liu, Wei Xu, et al.AB_647176 Anti-human CD8,eBioscience,Cat#: 48-0088-42; RRID: AB_1272062 Anti-human CD4,Biolegend,Cat#: 317416; RRID: AB_571945 Anti-human PD-1,BioLegend,Cat#: 329904; RRID: AB_940479 Anti-human Ki-67,BD Biosciences,Cat#:

(2) CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes ChemoresistanceCancer immunology researchMarch 1, 2023Lao L, Zeng W, Huang P, Chen H, Jia Z, Wang P, Huang D, Chen J, Nie Y, Yang L, et al.CD62 L (BioLegend, #304840), CD69 (BioLegend, #310905), CD103 (BioLegend, #350215), CD4 (BioLegend, #317416), IL17 (BioLegend, #512305), PD-1 (BioLegend, #135215), CTLA-4 (BioLegend, #349905), TIM-3 (BioLegend,

(3) MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cellsiScienceOctober 21, 2022Nicolas Bellini, Robert Lodge, Tram N.Q. Pham, Jaspreet Jain, Thomas T. Murooka, Alon Herschhorn, Nicole F. Bernard, Jean-Pierre Routy, CÃ©cile L. Tremblay, Ã‰ric A. Cohenanti-human CCR5 (BV421),BioLegend,Cat #359118; RRID: AB_2563577 Mouse anti-human CD4 (APC),BioLegend,Cat #317416; RRID: AB_571945 Mouse anti-human CD4 (PE/Cy7),BioLegend,Cat #317414; RRID: AB_571959 Mouse anti-human

(4) Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latencyRetrovirologyAugust 19, 2022Subha Dahal et al.only), anti-CD3-Pacific Blue (BioLegend, Cat#300330—CD4+ T cells only), anti-CD4-APC (BioLegend, Cat#317416), and LIVE/DEAD Fixable Blue (ThermoFisher, Cat#L34962), fixed and permeabilized using BD CytoFix/CytoPerm

(5) Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cellsEMBO reportsAugust 3, 2022Johannes Höfle et al.RPA‐T4),BD Biosciences,"Cat#555349, RRID:AB_398593" Mouse α‐human CD4 APC (clone OKT4),BioLegend,Cat#317416; RRID:AB_571945 Mouse α‐human CD4 BV711 (clone RPA‐T4),BioLegend,"Cat#300558, RRID:AB_2564393" Mouse

(6) Human immunodeficiency virus type 1 impairs sumoylationLife Science AllianceJune 1, 2022Bilgül Mete, Emre Pekbilir, Bilge Nur Bilge, Panagiota Georgiadou, Elif Çelik, Tolga Sutlu, Fehmi Tabak, Umut Sahin

(7) Immune disease variants modulate gene expression in regulatory CD4+ T cellsCell GenomicsApril 13, 2022Lara Bossini-Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail A. Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, et al.stained with the following antibody cocktail: anti-CD4-APC (30 μL/mL final volume, clone OKT4, Cat. no. 317416, BioLegend, San Diego, U.S.), anti-CD127-FITC and (30 μL/mL, clone eBioRDR5, Cat. no.11-1278-42, Thermo Fisher Scientific

(8) Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell SurfaceTissue Engineering Part AJanuary 1, 2022Yuki Okutani, Kengo Abe, Akihiro Yamashita, Miho Morioka, Shuichi Matsuda, Noriyuki TsumakiAnti-mouse IgG2a (isotype control)-PE,,1:100,M076-5,MBL Anti-human CD3-PE-Cy7,,1:20,557749,BD Biosciences Anti-human CD4-APC,,1:20,317416,BioLegend Anti-human CD8-PE,,1:5,555367,BD Biosciences Anti-CD159a (NKG2a)-APC,,1:10,A60797,BECKMAN

(9) TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancerCell reports. MedicineDecember 21, 2021Beatson RE, Parente-Pereira AC, Halim L, Cozzetto D, Hull C, Whilding LM, Martinez O, Taylor CA, Obajdin J, Luu Hoang KN, et al.RRID:AB_314074" CD4 – FITC (A161A1),BioLegend UK,"Cat# 357405, RRID:AB_2562356" CD4 – APC (OKT4),BioLegend UK,"Cat# 317416, RRID:AB_571945" CD8 – PE/Cy7 (SK1),BioLegend UK,"Cat# 344712, RRID:AB_2044008" CD8a – PE (RPA-T8),BioLegend

(10) Preclinical testing of chimeric antigen receptor T cells in neuroblastoma mouse modelsSTAR ProtocolsDecember 1, 2021Nan Li, Rosa Nguyen, Carol J. Thiele, Mitchell HoPerCP/Cyanine5.5 anti-human CD8a Antibody (5 μL/test),BioLegend,300924 APC anti-human CD4 Antibody (5 μL/test),BioLegend,317416 RPE F(ab’)2 goat anti-human IgG antibody (1:200 dilution),Jackson ImmunoResearch,109-116-170 Anti-GPC2

(11) EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cellsNature CommunicationsDecember 1, 2021Suyasha Roy, Zaigham Abbas Rizvi, Alexander J. Clarke, Felicity Macdonald, Abhaydeep Pandey, Dietmar Martin Werner Zaiss, Anna Kathrina Simon, Amit AwasthiPerCP (53-6.7; BioLegend Cat # 100732; 1:200) for mouse; and anti-human CD4 APC (OKT4, BioLegend Cat # 317416; 1:200) for human after live/dead marker staining respectively. For intracellular staining, cells were

(12) A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathwaySignal transduction and targeted therapyOctober 1, 2021Ma C, Ma X, Jiang B, Pan H, Liao X, Zhang L, Li W, Luo Y, Shen Z, Cheng X, et al.human peripheral blood were stained with anti-CD3-PE 7 (Biolegend, 300308), anti-CD4-APC (Biolegend, 317416), anti-CD8a-PE-Cy7 (Biolegend, 344750), anti-CD45RO-PerCP (Biolegend, 304251), and anti-CD62L-PE (Biolegend,

(13) Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccinationiScienceSeptember 24, 2021Carre C, Wong G, Narang V, Tan C, Chong J, Chin HX, Xu W, Lu Y, Chua M, Poidinger M, et al.H4A3",BD,563869 "L/D, AQUA,",Life Tech,L34966 "CD3, BV570, UCHT1",Biolegend,300436 "CD4, APC, OKT4",Biolegend,317416 "CD8a, AF700, RPA-T8",Biolegend,301028 "CD27, APC/Cy7, M-T271",Biolegend,356424 "CD57, PerCP/Cy5.5,

(14) Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumorsCellular & molecular immunologySeptember 1, 2021Wang Z, Li N, Feng K, Chen M, Zhang Y, Liu Y, Yang Q, Nie J, Tang N, Zhang X, et al.Coulter Inc.). The antibodies used are as follows: CD3-Pacific blue (300329), TCR-APC (306718), CD4-APC (317416), CD8-APC (301014), CD8-Brilliant Violet (301035), CD45RO-PE (304206), CCR7-Percp (353242) (all from

(15) The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cellsJournal of Biological ChemistrySeptember 1, 2021Rajesh Abraham Jacob et al.(#372705), Alexa Fluor 647 LAG-3 (#369303), APC Tim-3 (#345012), APC-Cy7 Tim-3 (#345026), APC CD4 (#317416), and APC/Cy7 HLA-A, B, C (#311426). The following isotype controls were used in this study: APC Mouse

(16) PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunityOncoImmunologyJuly 9, 2021Haiping Jiang et al.concanavalin A (Acro Biosystems, China) for 3 days and stained with APC-labeled anti-CD4 antibody (Cat. #317416, BioLegend) to gate CD4+ T cells. To check the co-expression of PD-L1 and LAG-3 in activated CD4+ T

(17) Microbial exposure during early human development primes fetal immune cellsCellJune 24, 2021Mishra A, Lai GC, Yao LJ, Aung TT, Shental N, Rotter-Maskowitz A, Shepherdson E, Singh GSN, Pai R, Shanti A, et al.(clone HI100) BV605,BD Biosciences,"Cat# 562886, RRID: AB_2737865" CD4 (clone OKT4) APC,BioLegend,"Cat# 317416, RRID: AB_571945" CD152/CTLA-4 (clone BNI3) PerCP/Cyanine5.5,BioLegend,"Cat# 369608, RRID: AB_2629674" CD25

(18) The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by VprCell host & microbeMay 12, 2021Dupont L, Bloor S, Williamson JC, Cuesta SM, Shah R, Teixeira-Silva A, Naamati A, Greenwood EJD, Sarafianos SG, Matheson NJ, et al.AB_306848 Rabbit anti-HLTF,Bethyl Laboratories,Cat#A300-230A; RRID: AB_2117307 Mouse anti-CD4-APC,Biolegend,Cat#317416; RRID: AB_571945 Mouse anti-LNGFR-PE,Biolegend,Cat#345106; RRID: AB_2152647 Rabbit anti-Histone H3K4me3,Cell Signaling

(19) HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responsesCell host & microbeMarch 10, 2021Clayton KL, Mylvaganam G, Villasmil-Ocando A, Stuart H, Maus MV, Rashidian M, Ploegh HL, Walker BD.anti-CD3-APC/Cy7 (Biolegend, Cat#300318, RRID:AB_314054), respectively, anti-CD4-APC (Biolegend, Cat#317416, RRID:AB_571945), and LIVE/DEAD Fixable Blue (ThermoFisher, Cat#L34962). Note, for the macrophages,

(20) Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I InterferonFrontiers in immunologyJanuary 1, 2021Soday L, Potts M, Hunter LM, Ravenhill BJ, Houghton JW, Williamson JC, Antrobus R, Wills MR, Matheson NJ, Weekes MP.

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3/6/2015Great antibody for detecting human CD4 expression Sojan AbrahamThis antibody was used for detecting human CD4 expression on human CD45 gated cells isolated from humanized mice. The results showed a clear CD4 positive and negative population which confirms the ... Read Review

APC anti-human CD4 from BioLegend

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APC anti-human CD4 from BioLegend

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