Fig 2: Results of the public database data analysis confirmed using qRT-PCR. In nine papillary thyroid carcinoma (PTC) samples with Hashimoto’s thyroiditis (HT) disease. (A) ABR was significantly upregulated in cancer tissues (PTC) compared to non-tumor adjacent tissue (NAT). (B) ADH1B was significantly downregulated in PTC compared to NAT. (C) LPAR5 was significantly upregulated in PTC compared to NAT. (D) SERPINA1 was significantly upregulated in PTC compared to NAT. The asterisks represent the significance of the difference, the more asterisks, the more significant the difference.

Fig 3: (A) Venn diagram showing the key genes of Hashimoto’s thyroiditis (HT) and papillary thyroid carcinoma (PTC) with area under the curve (AUC) values > 0.95 in the GSE33630 and GSE138198 datasets. (B) Receiver operating characteristic (ROC) curves of the four key genes (ADH1B, ABR, SERPINA1, LPAR5) in the HT and PTC in the GSE33630 dataset. (C) ROC curves of the four key genes (ADH1B, ABR, SERPINA1, and LPAR5) in HT and PTC in the GSE138198 dataset.