Fig 2: Violin plots and principal component analysis plots of model gene expression based on high and low risk. (A) The plot showing that GLCE expression values in the low-risk group are higher than those in the high-risk group; TPI1 expression values in the high-risk group are higher than those in the low-risk group. (B) The principal component analysis plot; red points representing localisation of the high-risk group on the right side of the PC1 axis and that of the low-risk group on the left side of the PC1 axis.

Fig 3: Plots of survival analysis. Plots (A, B) represent survival curves based on high and low expression of GLCE and TPI1. Plot (C) shows survival curves based on high and low risk of the model.

Fig 4: The molecular mechanism of COX5A over-expression on neurite outgrowth after OGD injury. a The relationship between Gstp1, Sod2, Rho-GDIa, TPI and COX5A predicted by GeneMANIA. b The mRNA expression of Rho GDP-dissociation inhibitor1. c The mRNA expression of Gstp1. d The mRNA expression of TPI. e The mRNA expression of Sod2. f The protein expression of TPI in each group. OGD oxygen glucose deprivation, NC negative control, COX5A cytochrome c oxidase subunit 5a over-expression, Gstp1 glutathione S-transferasp1, Sod2 Superoxide dismutase 2, Rho-GDIa guanine dissociation inhibitor a, TPI triosephosephate isomerase. N = 6/group. Data are presented as the mean ± SD. *p < 0.05, **p < 0.001