RUNX1 + RUNX2 Polyclonal Antibody from Bioss Inc.

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Supplier Page from
Bioss Inc. for
RUNX1 + RUNX2 Polyclonal Antibody

The RUNX1 + RUNX2 Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to RUNX family transcription factor 2, and RUNX2. This antibody recognizes Human, Mouse, Rat, Guinea Pig, and Rabbit antigen. The RUNX1 + RUNX2 Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.

Description

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation