The Glucocorticoid Receptor Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to NR3C1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Glucocorticoid Receptor Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth