Fig 1: Functional analysis of the Col4a1 and Col4a2 and their associated genes. (A) PPI of Col1a1, Col4a1, Col4a2, and their first neighbors. Blue nodes mark the genes, associated with either Col4a1, Col4a2, or both of them. (B) Venn diagram, demonstrating the overlap between the first neighbors of Col1a1, Col4a1, and Col4a2. (C) Histogram, visualizing functional enrichment analysis of Col4a1, Col4a2, and their first neighbors. Functional enrichment analysis was performed through the ToppFun module of the ToppGene suite, using the databases MSigDB Biocarta (v7.3), BioSystems: REACTOME and KEGG, Gene Ontology: biological processes and DisGeNET curated database. For all enrichment tools, the input gene set was composed of the same 15 genes and used with default options: significance threshold of 0.05 for adjusted p-value, at least two genes from the input list in the enriched category, and the whole genome as the reference background.