Description
Product Characteristics: FUNCTION: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15 % taste bud cells in circumvallate and foliate papillae but only in 2 % in fungiform papillae.,Mouse & Rat Taste R,Tas2r4, Tas2r108, Tas2r8, T2R4, Taste receptor type 2 member 8, TA2R4
Target Information: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity)