Western Blot analysis of 136752 and prefibrillar oligomers. 136752 (F) and prefibrillar oligomers (O) were run on SDS polyacrylamide gels, transferred to nitrocellulose and probed.

Extensive OC labeling was observed in the hippocampus (A), subiculum (B) and frontal cortex (C) in Alzheimer disease. A higher magnification photograph illustrates that OC positive deposits were dense and consisted of fine fibrillar material (D). Picture courtesy of Kayed et al., (2007) Biomed Central: Molecular Neurodegeneration, 2: 18.