Description
Product Characteristics: BEX1: FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. SUBUNIT: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. TISSUE SPECIFICITY: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve. DEVELOPMENTAL STAGE: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level). BEX2: SUBUNIT: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP. SUBCELLULAR LOCATION: Nucleus. Cytoplasm.,Brain Expressed X-linked,Brain expressed gene 1, BEX1, EG2RVC, BEX2, Brain-expressed X-linked protein 2 homolog
Target Information: Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity)