The Phospho-RAF1 (S43) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RAF1. This antibody recognizes Human, Mouse, and Rat antigen. The Phospho-RAF1 (S43) Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration