The ASK1(Phospho Thr838) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The ASK1(Phospho Thr838) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.:cofactor:Magnesium.:enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838: inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to: and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6: which in turn activate the JNK and p38 MAP kinases: respectively. Overexpression induces apoptotic cell death.:induction:By TNF-alpha. Inhibited by HIV-1 Nef.:Belongs to the protein kinase superfamily.:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.:Contains 1 protein kinase domain.:subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.:tissue specificity:Abundantly expressed in heart and pancreas.: