Anti-Cdc4 / Fbw7 / hSel 10 antibody ab12292 from Abcam

Product Specs
ItemAnti-Cdc4 / Fbw7 / hSel 10 antibody
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab12292
Antibody TypePrimary
Quantity100 UG
ApplicationsImmunocytochemistry/ Immunofluorescence, Western blot
ClonalityPolyclonal
IsotypeIgG
HostRabbit
Conjugate/TagUnconjugated
Concentration0.5 mg/ml
Gene NameFBXW7
ReactivityHuman
TargetCdc4 / Fbw7 / hSel 10

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β ProductionFrontiers in ImmunologyJanuary 5, 2022Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song, Lihua Lai, Meng Xia, Jianhua Zhang, Qingqing Wang(35). The following antibodies were used according to the manufacturers’ protocols: anti-Fbxw7 (Abcam, ab12292, RRID: AB_442966), anti-Lys48-specific linked polyubiquitin (MilliporeSigma, 05-1307, RRID: AB_1587578),

(2) Inhibition of chaperone‑mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancerMolecular Medicine ReportsMarch 12, 2021Ying Xuan, Shuang Zhao, Xingjun Xiao, Liwei Xiang, Hua-Chuan Zhenghomologue 1 (MLH1; cat. no. ab92312), Anti-F-box and WD40 domain protein 7 (FBXW7) antibody (cat. no. ab12292) and anti-multidrug resistance-associated protein 1 (MRP1; cat. no. ab233383) antibodies were purchased

(3) LncRNA XIST acts as a ceRNA sponging miR-185-5p to modulate pancreatic cancer cell proliferation via targeting CCND2Translational Cancer ResearchMarch 1, 2020Ya-Peng Wang, Yan Huang, Tao Hou, Min Lu(All purchased from Abcam, USA) as listed: CCND2 (ab207604, 1:1,000), CDC2 (ab32444, 1:1,000), CDC4 (ab12292, 1:500), CDC6 (ab109315, 1:1,000), CCND1 (ab134175, 1:10,000), Caspase-3 (ab13585, 1:500), Bcl-2 (ab32124,

(4) Interaction of YAP1 and mTOR promotes bladder cancer progressionInternational journal of oncologyJanuary 1, 2020Xu M, Gu M, Zhou J, Da J, Wang Z.Cell Signaling Technology, Inc.), SKP2 (1:1,000 dilution; cat. no. ab68455, Abcam), CDC4 (1:1,000 dilution; cat. no. ab12292, Abcam), RCHY1 (1:1,000 dilution; cat. no. 5754, Cell Signaling Technology, Inc.), UBE3A (1:1,000 dilution;

(5) Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammationThe Journal of clinical investigationJune 27, 2019He J, Song Y, Li G, Xiao P, Liu Y, Xue Y, Cao Q, Tu X, Pan T, Jiang Z, et al.polyubiquitin Ab (product no. 05-1307) was from MilliporeSigma. Abs against FBXW7 were obtained from Abcam (ab12292) and Thermo Fisher Scientific (40-1500). Abs against H3K36me3 (ab9050), H3K9me3 (ab8898), H3K4me3 (ab8580), H3K27me3

(6) E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responsesNature communicationsMarch 13, 2017Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, Xie Y, Chen S, Dong P, Chen L, et al.polyubiquitin antibody (05-1307, 1:1,000) was from Millipore. Antibodies to the FBXW7 were from Abcam (ab12292, 1:1,000) and Thermo Fisher (40-1500, 1:3,000). MG132 (M8699), CHX (C4859) and Flag-M2 Magnetic Beads

(7) Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migrationOncotargetOctober 9, 2015Xiao-Bin Lv et al.RIPA buffer and analyzed by Western blotting. The human anti-Fbxw7α antibody was obtained from Abcam (ab12292). Human anti-SOX10 (sc-17342) anti-GSK3β (sc-53931) and anti-GAPDH (sc-166574) antibodies were obtained

(8) Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1Experimental cell researchAugust 1, 2013Biswas M, Kwong EK, Park E, Nagra P, Chan JY.

(9) FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradationLeukemiaMay 1, 2013A Malyukova et al.Cruz, CA, USA), anti-Actin, antiFlag (M2) (Sigma-Aldrich, Sydney, Australia), anti-tubulin, anti-FBXW7 (ab12292-100) (Abcam, Cambridge, UK); anti-Mcl1 (Y37) (Cell Signaling, Danvers, MA, USA); anti-GR (BD biosciences,

(10) FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4Nature communicationsJanuary 1, 2013Balamurugan K, Sharan S, Klarmann KD, Zhang Y, Coppola V, Summers GH, Roger T, Morrison DK, Keller JR, Sterneck E.

(11) PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cellsOncogeneMarch 22, 2012Mannava S, Omilian AR, Wawrzyniak JA, Fink EE, Zhuang D, Miecznikowski JC, Marshall JR, Soengas MS, Sears RC, Morrison CD, et al.sc-80659, sc-93, sc-7383, respectively); C-MYC-Ser-62, PP2A-B56α and Fbw7 from Abcam (ab78318, ab1084 and ab12292, respectively); p16INK4A PIN1, USP28, from Cell Signaling Technology (4824, 3722, 4217s); from SPP2A-C

(12) The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysisThe Journal of biological chemistryNovember 11, 2011Madhurima Biswas, Diane Phan, Momoko Watanabe, Jefferson Y Chan

(13) The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifsThe Journal of biological chemistryJune 11, 2010Ning Liu, Hui Li, Shuangxi Li, Mingyue Shen, Ning Xiao, Yunfei Chen, Yan Wang, Weichao Wang, Rui Wang, Qian Wang, Jianhua Sun, Ping Wang

(14) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7OncogeneMay 20, 2010V Rocher-Ros, S Marco, J-H Mao, S Gines, D Metzger, P Chambon, A Balmain, C A Sauraand cleaved-Notch1 (Val1744) were from Cell Signaling (Beverly, MA, USA). We used rabbit anti-Fbw7 (Ab12292; Abcam, Cambridge, UK), PS1NT (Calbiochem, San Diego, CA, USA), PS2 (Oncogene, Cambridge, MA, USA) and

(15) Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 proteinProceedings of the National Academy of Sciences of the United States of AmericaOctober 9, 2007Ke Lan, Subhash C Verma, Masanao Murakami, Bharat Bajaj, Rajeev Kaul, Erle S Robertson

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Anti-Cdc4 / Fbw7 / hSel 10 antibody from Abcam

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Anti-Cdc4 / Fbw7 / hSel 10 antibody from Abcam

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