PLCgamma2 Antibody 3872S from Cell Signaling Technology

Product Specs
ItemPLCgamma2 Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number3872S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetPLCg2
HostRabbit
NCBI Full Gene Namephospholipase C gamma 2
ClonalityPolyclonal
NCBI Gene AliasesAPLAID, FCAS3, PLC-IV, PLC-gamma-2
Research AreaCa, cAMP and Lipid Signaling
Molecular Weight150

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Disease-related PSS1 mutant impedes the formation and function of osteoclastsJournal of Lipid ResearchNovember 1, 2023Sari Sugahara, Yuki Ishino, Koki Sawada, Tsumugi Iwata, Yuta Shimanaka, Junken Aoki, Hiroyuki Arai, Nozomu Konopurchased from Sigma-Aldrich. Antibodies to Src (#2110), pSrc (Y416) (#2101), phospholipase C γ2 (PLCγ2) (#3872), and phosphorylated PLCγ2 (Y1217) (#3871) were purchased from Cell Signaling Technology, Inc. Antibody

(2) Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cellsFrontiers in PharmacologySeptember 9, 2022Weam Othman Elbezanti et al.anti-phospho-BTK (#5082), rabbit anti-BTK (#8547), rabbit anti-phospho-PLCγ2 (#3871), rabbit anti-PLCγ2 (#3872) were obtained from Cell Signaling Technology (Danvers, MA). Antibodies against GAPDH, Hoechst 33342,

(3) Inhibition of O-GlcNAcylation Decreases the Cytotoxic Function of Natural Killer CellsFrontiers in ImmunologyApril 11, 2022Daniel Feinberg, Parameswaran Ramakrishnan, Derek P. Wong, Abhishek Asthana, Reshmi Parameswaran(5861T), p-AKT at T308 (13038T), pan AKT (4691), ERK/p42/p44 (4695T), p-ERK T202/Y204 (9101S), PLCgamma2 (3872T), STAT5 (25656), and p-STAT5 Y694 (9351S)—all from Cell Signaling Technology normalized to beta-actin

(4) Kangbainian Lotion Ameliorates Vulvovaginal Candidiasis in Mice by Inhibiting the Growth of Fluconazole-Resistant Candida albicans and the Dectin-1 Signaling Pathway ActivationFrontiers in PharmacologyJanuary 20, 2022Zewei Chen, Tengshuo Luo, Fengke Huang, Fuzhen Yang, Wenting Luo, Guanfeng Chen, Mengfei Cao, Fengyun Wang, Jun Zhang(1:1,000, Cell Signaling Technology, 13198T, United States), PLCγ-2 (1:1,000, Cell Signaling Technology, 3872T, United States), CARD9 (1:500, Affinity, DF8387, China), NF-κB (1:1,000, Cell Signaling Technology,

(5) Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent mannerPharmaceutical BiologyNovember 12, 2021Tongtong Sui, Bojun Qiu, Jiaorong Qu, Yuxin Wang, Kunnian Ran, Wei Han, Xiaozhong Peng(2938S, CST), anti-p-AKT (9018S, CST), anti-Erk1/2 (4695 T, CST), anti-p-Erk1/2 (4370S, CST), anti-PLCγ (3872 T, CST), anti-p-PLCγ (3871 T, CST), anti-PARP (9542 L, CST), anti-caspase-3 (9665S, CST), anti-cleaved-caspase-3

(6) Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signalingLife science allianceNovember 1, 2021Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B.anti-SYK (4D10.2) from BioLegend. The antibodies directed against; BTK-pY223, #5082; PLCγ1, #5690; PLCγ2, #3872; PLCγ2-pY759, #3874; SYK-p525/526, #2710; ERK, #4695; ERK-pT202/Y204, #4370; GRB2, #3972; and GAPDH,

(7) PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophagesScientific reportsOctober 6, 2021Obst J, Hall-Roberts HL, Smith TB, Kreuzer M, Magno L, Di Daniel E, Davis JB, Mead E.(Y525/Y526),rabbit,Thermo Scientific,MA514918,1:500 Total SYK,mouse,Genetex,GTX31122,1:1000 Total PLCγ2,rabbit,CST,3872S,1:500 Phospho-p44/42 MAPK (T202/Y204),rabbit,CST,4370S,1:1000 Total p44/42 MAPK,rabbit,CST,4695S,1:1000 TREM2,rabbit,Abcam,ab209814,1:500 GAPDH,rabbit,Sigma,G9545,1:2000 Primary

(8) Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and ThrombosisInternational Journal of Molecular SciencesSeptember 30, 2021Samantha F. Moore, Ejaife O. Agbani, Andreas Wersäll, Alastair W. Poole, Chris M. Williams, Xiaojuan Zhao, Yong Li, James L. Hutchinson, Roger W. Hunter, Ingeborg Hersphospho-GSK3α/βS21/9 (#8566), GS (#3839), phospho-GSS641 (#3891), LAT (#9166), phospho-LATY191 (#3584), PLCγ2 (#3872), phospho-PLCγ2Y759 (#3874), Syk (#2717) and phospho-SykY525/526 (#2711) antibodies were from Cell Signalling

(9) The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphomaiScienceSeptember 24, 2021Dhananjaya Pal, Kendra R. Vann, Shweta Joshi, Namood E. Sahar, Guillermo A. Morales, Dalia El-Gamal, Tatiana G. Kutateladze, Donald L. Durden13748S anti-pT58MYC antibody,Abcam,Cat. # ab28842 anti-pPLCγ2-Y759 antibody,Cell Signaling Tech.,Cat. # 3872S total anti-PLCγ2 antibody,Cell Signaling Tech.,Cat. # 3872 anti-β-actin antibody,Cell Signaling Tech.,Cat.

(10) Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activationCommunications biologyJuly 22, 2021Dhar P, Basher F, Ji Z, Huang L, Qin S, Wainwright DA, Robinson J, Hagler S, Zhou J, MacKay S, et al.phospho-JNK (Thr183/Tyr185) (CST, 9251), JNK (CST, 9252), phospho-PLCγ2 (Tyr1217) (CST, 3871), PLCγ2 (CST, 3872), Vav1 (CST, 2502), SLP-76 (CST, 70896), β-actin (CST, 3700), DAG lipase β (CST, 12574), phospho-IP3

(11) Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphomaMolecular therapy oncolyticsJune 25, 2021Yu H, Wang X, Li J, Ye Y, Wang D, Fang W, Mi L, Ding N, Wang X, Song Y, et al.against phospho-Tyr223-BTK, BTK (no. 8547), ITK (no. 2380), phospho-Tyr759-PLCγ2 (no. 3874), PLCγ2 (no. 3872), phospho-Tyr1068-EGF Receptor (D7A5) XP rabbit monoclonal antibody (mAb) (no. 3777), EGF receptor (no.

(12) The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from plateletsNature communicationsJune 7, 2021Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, et al.Cell Signaling Technology, #3871S, 1:1000), total PLCγ2 (Cell Signaling Technology, Danvers, USA, #3872S, 1:1000); phospho PKA (PKA α/β/γ catalytic subunit phospho T197, Abcam, #ab75991, 1:3000), total PKA

(13) Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen SpeciesFrontiers in PharmacologyJune 3, 2021Delong Chen et al.P38 (Cat# 9212L), p-P65 (Cat# 3033S), P65 (Cat# 8242S), p-PLC gamma2 (Cat# 3871S), PLC gamma2 (Cat# 3872S), MMP9 (Cat# 13667S), c-Fos (Cat# 2250S), HO-1 (Cat# 70081S) and catalase (Cat# 12980S) were acquired

(14) Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancerMolecular CellMay 1, 2021Teresa Sadras et al.antibody,Cell Signaling,8032 PLCγ2-pY1217 antibody,Cell Signaling,3871 PLCγ2 antibody,Cell Signaling,3872 PLCγ1-pY783 antibody,Cell Signaling,2821 PLCγ1 antibody,Cell Signaling,5690 Streptavidin-HRP antibody,ThermoFisher,21130 SYK-pY352

(15) Apoptosis signal‐regulating kinase 1 regulates immune‐mediated thrombocytopenia, thrombosis, and systemic shockJournal of Thrombosis and HaemostasisNovember 1, 2020Pravin Patel, Noor F. Shaik, Yuhang Zhou, Kalyan Golla, Steven E. McKenzie, Ulhas P. Naik1:1000 (against-human & mouse)]. Anti-P-PLCγ2 (Y759) [#3874, 1:1000 (against-mouse)]; Anti-PLCγ2 [#3872S, 1:1000 (against-mouse)]. Anti-P-cPLA2 (S505) [#2831S, 1:1000 (against-mouse)]; and, Anti-rabbit IgG,

(16) Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosisNature communicationsJune 25, 2020van der Wel T, Hilhorst R, den Dulk H, van den Hooven T, Prins NM, Wijnakker JAPM, Florea BI, Lenselink EB, van Westen GJP, Ruijtenbeek R, et al.polyclonal rabbit anti-phospho-PLCγ2 Y1217 (1:1000, CST, #3871), polyclonal rabbit anti-PLCγ2 (1:1000, CST, #3872). Secondary antibodies: goat anti-mouse-HRP (1:5000, Santa Cruz, sc-2005), goat anti-rabbit-HRP (1:5000,

(17) The diagnostic value of extracellular protein kinase A (ECPKA) in serum for gastric and colorectal cancerTranslational Cancer ResearchJune 1, 2020Yan Wu, Yafang Li, Junqiang Liu, Mengjiao Chen, Wei Li, Yongchang Chen, Min Xuhttp://dx.doi.org/10.21037/tcr-20-764 Wu et al. The value of ECPKA for gastric and colorectal cancer 3872 β-actin were purchased from Cell Signaling Technology (Danvers, MA, USA). Electrochemiluminescence

(18) Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasmsNature communicationsMay 8, 2020Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn YK, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida MJ, Pojer F, et al.anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10), 1:1000, Cell Signaling #9106; anti-PLCƴ2, dilution 1:1000, Cell Signaling, #3872; anti-PLCƴ2 (Tyr1217), 1:1000, Cell Signaling #3871; anti-Flag, 1:5000, Sigma # F3165; anti-Penta-his,

(19) Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infectionPLoS pathogensMay 1, 2020Shaban L, Nguyen GT, Mecsas-Faxon BD, Swanson KD, Tan S, Mecsas J.(Millipore; Cat# 05–1426), anti- SLP76pY128 (BD Pharmingen; Cat# 558367), anti-PLCγ2 (Cell Signaling; Cat# 3872), anti-PLCγ2pY1217 (Cell Signaling; Cat# 3871), antiErk1/2 pThr202/pTyr204 (Cell Signaling; Cat# 4370),

(20) Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2HaematologicaApril 30, 2020Joshua H. Joshua H. Bourne, Martina Martina Colicchia, Ying Ying Di, Eleyna Eleyna Martin, Alexander Alexander Slater, Lubka T. Lubka T. Roumenina, Jordan D. Jordan D. Dimitrov, Steve P. Steve P. Watson, Julie Julie RayesPhospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (#2710), Phospho-PLCγ2 (Tyr759) antibody (#3874), Syk antibody (#2712) and PLCγ2 antibody (#3872) were used (Cell signalling). Protein phosphorylation was assessed after 6 min of aggregation as previously

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PLCgamma2 Antibody

PLCgamma2 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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PLCgamma2 Antibody from Cell Signaling Technology

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