Anti-PI 3 Kinase p110 delta antibody ab1678 from Abcam

Product Specs
ItemAnti-PI 3 Kinase p110 delta antibody
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab1678
Antibody TypePrimary
Quantity100 UG
IsotypeIgG
ApplicationsImmunocytochemistry/ Immunofluorescence
HostRabbit
ClonalityPolyclonal
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NamePIK3CD
ReactivityHuman
TargetPI 3 Kinase p110 delta

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Epimedium sagittatum Maxim ameliorates adriamycin-induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathwayImmunity, inflammation and diseaseJune 1, 2023Wang R, Zeng M, Zhang B, Zhang Q, Xie S, Hu Y, Fan R, Wang M, Yu X, Zhang Y, et al.Oxygenase‐1 (HO‐1, A19062, ABclonal), NAD(P)H Quinone Dehydrogenase 1 (NOQ‐1, A19586, ABclonal), PI3K (ab1678, Abcam), AKT (ab8805, Abcam), Phospho‐Akt (p‐AKT, ab66138, Abcam) and β‐actin (Ac026, ABclonal). The

(2) PI 3‐kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNSEMBO Molecular MedicineAugust 7, 2020Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, et al.1:400, Promega G7121), PTEN (D4.3) XP (rabbit, 1:100, Cell Signaling 9188S), p110δ (rabbit, 1:500, Abcam ab1678), Brn3a (C‐20) (goat, 1:200, Santa Cruz sc‐31984). ARF6, (rabbit, 1:100, Abcam ab77581), GST (1:400,

(3) MiR-33a-5p inhibits the growth and metastasis of melanoma cells by targeting SNAI2NeoplasmaJuly 1, 2020Zhang ZR, Yang N.Vimentin (1:1000, ab137321, Abcam), Snail (1:1000, ab53519, Abcam), SNAI2 (1:500, ab180714, Abcam), PI3K (1:1000, ab1678, Abcam), p-AKT308 (1:1000, #2965, Santa Cruz Biotechnology, Shanghai, China), AKT (1:3000, ab179463, Abcam),

(4) Effects of PI3K Inhibition on Afucosylated Antibody–Driven FcγRIIIa Events and Phospho-S6 Activity in NK CellsThe Journal of ImmunologyJuly 1, 2019Valentina Romeo, Sarah Gierke, Kyle A. Edgar, Scot D. LiuPrime (GE Healthcare). Abs used were as follows: PI3Ka-Abcam ab40776, PI3Kb-Abcam ab32569, PI3Kd-Abcam ab1678, PI3Kg-Abcam ab32089, p-AKT (S473)-CST 4060, p-AKT (T308)-CST 2965, p-S6–CST 2211, p-PRAS40–CST 13175,

(5) CD40L inhibits cell growth of THP-1 cells by suppressing the PI3K/Akt pathwayOncoTargets and TherapyMay 23, 2019Zhongxin Feng, Qi Chen, Mingqiang Ren, Zuguo Tian, Yuping Gongantibody (ab65854, 1:500; Abcam); rabbit anti-human polyclonal antiPI3 kinase p110 delta antibody (ab1678, 1:3,000; Abcam); rabbit anti-human monoclonal phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (#4060, 1:3,000

(6) PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaJournal of Experimental MedicineMay 6, 2019Yong Jae Shin et al.(AP8041b; Abgent), pAKT 1:200 (4060S; Cell Signaling), p85 1:100 (ab86714; Abcam), and p110 1:100 (ab1678; Abcam). Immunostaining analysis Cells and tissues were fixed in 4% PFA for 20 min. After blocking

(7) Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFRChinese Medical JournalFebruary 20, 2019Xue-Ling Mei, Shan Zhongrabbit polyclonal primary antibodies at 4°C overnight: anti-EGFR (1:1000, ab5644), anti-PI3K (1:2000, ab1678), anti-p-AKT (1:500, ab8805), anti-VEGF (1:1000, ab11939), anti-MMP-2 (1:1000, ab37150), anti-MMP-9

(8) Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF‑1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase‑3 signaling pathway in small cell lung cancerOncology LettersSeptember 24, 2018Wenli Jiang, Linghong Meng, Guangming Xu, Cuiting Lv, Hongliang Wang, He Tian, Ruohua Chen, Binghua Jiao, Bingui Wang, Caiguo Huangfamily 1 member C1 (AKR1C1)/AKR1C2 (ab96087; 1:1,000), anti-p-PI3K (ab182651; 1:1,000), anti-PI3K (ab1678; 1:1,000), anti-AKT (ab179463; 1:1,000) and anti-p-AKT (ab81283; 1:1,000) were purchased from Abcam

(9) Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophagesCell Death & DiseaseJune 7, 2018Evangelia Goulielmaki, Miriam Bermudez-Brito, Margarita Andreou, Niki Tzenaki, Maria Tzardi, Eelco de Bree, Eleftheria Tsentelierou, Antonis Makrigiannakis, Evangelia A. Papakonstanti°C overnight using an anti-PTEN (Santa Cruz Biotechnology #A2B1 or #sc-6818) or anti-p110δ (Abcam #ab1678) antibody respectively. Immune complexes were collected with 50% slurry of protein A-Sepharose after

(10) TNF‑α increases inflammatory factor expression in synovial fibroblasts through the toll‑like receptor‑3‑mediated ERK/AKT signaling pathway in a mouse model of rheumatoid arthritisMolecular Medicine ReportsApril 19, 2018Fang‑Yuan Yu, Cong‑Qin Xie, Chang‑Liang Jiang, Ji‑Tong Sun, Xun‑Wu Huang(1:1,000; ab6671, Abcam), IL‑1β (1:1,000, ab200478), IL‑4 (1:1,000, ab9728), IL‑6 (1: 500; ab7737), PI3K (1:2,000; ab1678), ERK (1:2,000; ab196883), pERK (1:2,000; ab214362), AKT (1:1,000; ab8805), pAKT (1:1,000; ab133458;

(11) Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211Cellular Physiology and BiochemistryJanuary 15, 2018Donghui Xu, Guonan Chi, Conghai Zhao, Dongyuan Li(ab25758), Bcl-2 (ab59348), Bax (ab53154), MMP2 (ab37150), MMP-9 (ab73734), Vimentin (Vim; ab137321), PI3K (ab1678), p-PI3K (ab182651), p-AKT (ab131443), mTOR (ab2732), p-mTOR (ab84400), S6K (ab9366), p-S6K(ab2571),

(12) Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouseJournal of immunology (Baltimore, Md. : 1950)July 15, 2014Suárez-Fueyo A, Rojas JM, Cariaga AE, García E, Steiner BH, Barber DF, Puri KD, Carrera AC.

(13) PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke modelNature communicationsMarch 14, 2014Low PC, Manzanero S, Mohannak N, Narayana VK, Nguyen TH, Kvaskoff D, Brennan FH, Ruitenberg MJ, Gelderblom M, Magnus T, et al.in 0.1% Triton X-100/ PBS for 5 min before incubation for 1 h with rabbit anti-PI3Kd antibody (Abcam ab1678, 1:400)51 and mouse anti-bIII-tubulin (Covance MMS-435P, 1:1,000), goat anti-Iba1 (Abcam ab5076, 1:500)

(14) Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell functionPloS oneJanuary 1, 2014Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA.

(15) The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shockNature ImmunologyNovember 1, 2012Ezra Aksoy et al.

(16) Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell deathJournal of immunology (Baltimore, Md. : 1950)September 1, 2011Suárez-Fueyo A, Barber DF, Martínez-Ara J, Zea-Mendoza AC, Carrera AC.Technology), goat anti-PTEN, rabbit anti-p110g (SC-7177; Santa Cruz Biotechnology), and rabbit anti-p110d (ab1678, Abcam) Abs. For immunoprecipitation, we used the same Ab or anti-CD28 (Biosource International), -p110d

(17) Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancerBreast Cancer ResearchApril 1, 2011Cesar G Sanchez, Cynthia X Ma, Robert J Crowder, Therese Guintoli, Chanpheng Phommaly, Feng Gao, Li Lin, Matthew J Ellisfactor receptor 2 (HER2) (#A0485; Dako, Carpenteria, CA, USA), phospho-Y1248-HER2 (#M7269; Dako), p110δ (ab1678; AbCam, Cambridge, MA, USA) and actin (sc-1616; Santa Cruz Biotechnology, Santa Cruz, CA, USA). Antibodies

(18) Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoformsPloS oneJanuary 1, 2011Enrico Conte, Mary Fruciano, Evelina Fagone, Elisa Gili, Filippo Caraci, Maria Iemmolo, Nunzio Crimi, Carlo Vancheri

(19) Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretionJournal of Cell BiologySeptember 20, 2010Pei Ching Low, Ryo Misaki, Kate Schroder, Amanda C. Stanley, Matthew J. Sweet, Rohan D. Teasdale, Bart Vanhaesebroeck, Frédéric A. Meunier, Tomohiko Taguchi, Jennifer L. Stow

(20) The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell developmentScience signalingAugust 10, 2010Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K.Signaling Technology, CST 4249), antibody against p110β (CST 3011), antibody against p110δ (Abcam, ab1678), antibody against Akt (CST 9272), antibody against Akt pSer473 (CST 4058), antibody against pERK1/2

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Anti-PI 3 Kinase p110 delta antibody from Abcam

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Anti-PI 3 Kinase p110 delta antibody from Abcam

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