InVivoMab anti-human CD4 BE0288-R001mg from Bio X Cell

Description

Bio X Cell InVivoMAb anti-human CD4 Monoclonal Antibody has the following reported applications: in vitro CD4 blockade, in vitro blocking of CD4+ T cell activation, Immunofluorescence, Immunohistochemistry (frozen), Flow cytometry. It features greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free

Product Specs
ItemInVivoMab anti-human CD4
CompanyBio X Cell
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberBE0288-R001mg
Quantity1 mg
Applicationsin vitro CD4 blockade, in vitro blocking of CD4+ T cell activation, Immunofluorescence, Immunohistochemistry (frozen), Flow cytometry
ConcentrationLot specific,typically between 4-11 mg/ml
Conjugate/TagUnconjugated
ReactivityHuman
TargetCD4
IsotypeIgG1, κ
CloneRPA-T4
Hostmouse
NCBI Full Gene NameCD4 antigen
NCBI Gene AliasesL3T4, Ly-4
ClonalityMonoclonal
Antibody TypePrimary Antibody
Purity>95%, Determined by SDS-PAGE
FormatPBS, pH 7.0, Contains no stabilizers or preservatives
Research AreaImmunology

Specifications/Features

Other available quantities: Available in 1, 5, 10, 25, 50, 100 mg and bulk sizes. Academic discount available.

Endotoxin: <2EU/mg (<0.002EU/µg), Determined by LAL gel clotting assay

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Bio X Cell

39 Labombard Rd

Lebanon, NH 03766

United States

Phone: 1-866-787-3444

Email: customerservice@bxcell.com

Company Profile

Website: bioxcell.com

(1) Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entryBiochimica et biophysica actaSeptember 1, 2016Moolla N, Killick M, Papathanasopoulos M, Capovilla A.

(2) CD4 blockade directly inhibits mouse and human CD4(+) T cell functions independent of Foxp3(+) TregsJournal of autoimmunityDecember 1, 2013Mayer CT, Huntenburg J, Nandan A, Schmitt E, Czeloth N, Sparwasser T.

(3) Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumabJournal of virologyApril 1, 2011Toma J, Weinheimer SP, Stawiski E, Whitcomb JM, Lewis ST, Petropoulos CJ, Huang W.

(4) Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammationPediatric researchJuly 1, 2004Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD.

(5) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cellsCellMarch 3, 2000Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, et al.

(6) CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoirJournal of virologyOctober 1, 1999Moir S, Lapointe R, Malaspina A, Ostrowski M, Cole CE, Chun TW, Adelsberger J, Baseler M, Hwu P, Fauci AS.

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