Anti-TMPRSS2 antibody [EPR3861] ab92323 from Abcam

Product Specs
ItemAnti-TMPRSS2 antibody [EPR3861]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab92323
Conjugate/TagUnconjugated
CloneEPR3861
IsotypeIgG
HostRabbit
Antibody TypePrimary
Quantity10 UL, 40 UL, 100 UL
ApplicationsImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
ClonalityMonoclonal
Gene NameTMPRSS2
ReactivityHuman, Mouse, Rat
TargetTMPRSS2

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concerniScienceAugust 18, 2023Yu Onodera, Jady Liang, Yuchong Li, Bryan Griffin, Thenuka Thanabalasingam, Cong Lu, JiaYi Zhu, Mingyao Liu, Theo Moraes, Wenhua Zheng, et al.AB_10865716 RAGE,Abcam,Cat# AB37647; RRID: AB_777613 ERα,Abcam,Cat# AB32063; RRID: AB_732249 TMPRSS2,Abcam,Cat# AB92323; RRID: AB_10585592 B-actin,Sigma,Cat# A5316; RRID: AB_476743 Pro-SPC,Millipore Sigma,Cat# AB3786;

(2) TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTSJournal of Molecular Cell BiologyAugust 3, 2023Danielle Cicka, Qiankun Niu, Min Qui, Kun Qian, Eric Miller, Dacheng Fan, Xiulei Mo, Andrey A Ivanov, Stefan G Sarafianos, Yuhong Du, et al.secondary antibody (115-035-003) were purchased from Jackson ImmunoResearch. Anti-TMPRSS2 antibody (ab92323) was purchased from Abcam. TR-FRET assay development Various combinations of constructs were co-transfected

(3) The role of high cholesterol in SARS-CoV-2 infectivityJournal of Biological ChemistryJune 1, 2023Hao Wang, Zixuan Yuan, Mahmud Arif Pavel, Sonia Mediouni Jablonski, Joseph Jablonski, Robert Hobson, Susana Valente, Chakravarthy B. Reddy, Scott B. Hansen[Abcam, #ab189168], anti-Furin antibody [Abcam, #ab3467], or anti-TMPRSS2 antibody [EPR3861] [Abcam, #ab92323]) for 60 min in 5% BSA/0.05% Triton/PBS at room temperature followed by five washes with 1% BSA/0.05%

(4) Detection of SARS-CoV-2 and Its Related Factors on the Mucosal Epithelium of the TongueACTA HISTOCHEMICA ET CYTOCHEMICAApril 25, 2023Jun Tamiya, Wakako Sakaguchi, Kimiko Nakagawa, Toshiharu Yamamoto, Juri Saruta, Nobuhisa Kubota, Akira Kawata, Iwao Hasegawa, Nobushiro Hamada, Keiichi TsukinokiAntibody,Clone,Supplier,Dilution for IHC,Retorival ACE2,HPA000288,"Sigma-Aldrich, MO, USA",500,Citrate buffer (pH6) TMPRSS2,ab92323,"Abcam, Cambridge, UK",1000,Tris-EDTA (pH9) S-protein,3525,"ProSci, CA, USA",2000,Tris-EDTA (pH9) Ki67,MIB-1,"Dako,

(5) A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral InfectionsAdvanced ScienceMarch 1, 2023Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grißmer, Annette Boese, Gilles Gasparoni, Abdulrahman Salhab, Ralf Seipelt, Klaus Urbschat, Clémentine Richter, et al.antibody, #ab15348, Abcam), TMPRSS2 (1:1000 dilution, Recombinant Anti‐TMPRSS2 antibody [EPR3861], #ab92323, Abcam), and GAPDH (1:1000 dilution, Anti‐G3PDH Human Polyclonal Antibody, #2275‐PC‐100, Trevigen) allowed

(6) Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platformiScienceFebruary 17, 2023Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, et al.dilution, #ab15348, Abcam), and TMPRSS2 (1:1000 dilution, Recombinant Anti-TMPRSS2 antibody [EPR3861], #ab92323, Abcam) followed by incubation with IRDye-labeled secondary antibodies (LI-COR Biotechnology, IRDye800CW

(7) Apalutamide Prevents SARS-CoV-2 Infection in Lung Epithelial Cells and in Human Nasal Epithelial CellsInternational Journal of Molecular SciencesFebruary 7, 2023Amene Majidipur, Margot Morin-Dewaele, Jeanne Gaspar Lopes, Francois Berry, Julien Fouchet, Sophie Bartier, Anais Dufros Duval, Pascale Soyeux, Eric Huet, Bruno Louis, et al.directed against the following proteins: TMPRSS2 (ab109131, 1/1000, Abcam, Cambridge, UK), TMPRSS2 Nt (ab92323,1/1000, Abcam, Cambridge, UK), AR (sc-816, 1/1000, Santa-cruz, CA, USA), GAPDH (ab8245, Abcam, Cambridge,

(8) Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epitheliumMucosal ImmunologyFebruary 1, 2023Nino Stocker, Urszula Radzikowska, Paulina Wawrzyniak, Ge Tan, Mengting Huang, Mei Ding, Cezmi A. Akdis, Milena SokolowskaAbcam, Cambridge, UK), rabbit anti-ACE2 (1:1000, HPA000288, Sigma-Aldrich), rabbit anti-TMPRSS2 (1:1000, ab92323, Abcam), rabbit anti-NRP1 (1:50, HPA030278, Sigma-Aldrich), HRP-conjugated anti-rabbit (1:10000, 11-035-003,

(9) PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infectionProceedings of the National Academy of Sciences of the United States of AmericaJanuary 31, 2023Wang L, Wang S, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM.GAPDH (Proteintech, HRP-60004), PCIF1 (Proteintech, 16082-1), ACE2 (Novus, NBP2-67692), TMPRSS2 (Abcam, ab92323), and NRP1 (Abcam, ab81321). RNA Purification and qRT-PCR. RNA was extracted using a Quick-RNA Miniprep

(10) Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2Cell DiscoveryJanuary 6, 2023Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Gengfu Xiao, et al.China), hACE-2 (ab108252, Abcam, UK), NRP-1 (ab81321, Abcam, UK), AXL (ab215205, Abcam, UK), TMPRSS2 (ab92323, Abcam, UK) GAPDH (30201ES60, Yeasen, China), N protein (A20021, ABclonal, China), Caspase-3 (14220,

(11) SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19Research (Washington, D.C.)January 1, 2023Ma X, Liang J, Zhu G, Bhoria P, Shoara AA, MacKeigan DT, Khoury CJ, Slavkovic S, Lin L, Karakas D, et al.Cell Signaling), anti-spike antibody (ZMS1076, Sigma), anti-transmembrane protease serine 2 antibody (AB92323, Abcam). or anti-glyceraldehyde-3-phosphate dehydrogenase antibody (5174, Cell Signaling) overnight

(12) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry modelJournal of virus eradicationDecember 1, 2022Endo Y, Hickerson BT, Ilyushina NA, Mohan N, Peng H, Takeda K, Donnelly RP, Wu WJ.primary antibodies were used for Western Blot analysis: ACE2 (Abcam, cat# ab15348), TMPRSS2 (Abcam, cat# ab92323), EGFR (BD Biosciences, cat# 610016), phospho-EGFR (Y1045) (Cell Signaling Technology, cat# 22371),

(13) New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extractsCell Death DiscoveryDecember 1, 2022Bo Wang, Dongping Li, Anna Fiselier, Igor Kovalchuk, Olga Kovalchuk(CB2, Cat# ab3561), COX2 (Cat# ab15191), IFNGR1 (Cat# ab134070), IL-8 (Cat# ab18672), TMPRSS2 (Cat# ab92323), TNFR2 (Cat# ab109322) (all from Abcam, Cambridge, UK), NF-κB p65 (#8242), phospho-NF-κB p65 (Ser536,

(14) Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infectionFront ImmunolNovember 3, 2022Shima Shahbaz, Olaide Oyegbami, Suguru Saito, Mohammed Osman, Wendy Sligl, Shokrollah Elahithe staining of TMPRSS2, samples were incubated in 100 µL of TMPRSS2 primary antibody (1:200 Abcam ab92323) overnight in a moist chamber at 4°C. For the negative control, samples were incubated with 100 µL PBS

(15) Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cellsBMC molecular and cell biologySeptember 29, 2022Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C.(21115-1-AP, 1:1000, Proteintech, USA), anit-AGTR1 (25343-1-AP, 1:500, Proteintech, USA), anti-TMRRSS2 (ab92323, 1:1000, Abcam, UK), anti-ISG15 (15981-1-AP, 1:500, Proteintech, USA), anti-phospho-MAPK14 (28796-1-AP,

(16) Structurally Modified Bioactive Peptide Inhibits SARS-CoV-2 Lentiviral Particles ExpressionPharmaceuticsSeptember 26, 2022Khushwant S. Bhullar, Manal A. Nael, Khaled M. Elokely, Steven J. Drews, Jianping Wupurchased from Gibco/Invitrogen (Carlsbad, CA, USA). Antibodies reactive to ACE2 (ab108252), TMPRSS2 (ab92323), Furin (ab183495), recombinant Anti-SARS-CoV-2 Spike Glycoprotein S1 antibody (ab283942) and total OXPHOS Rodent WB Antibody Cocktail

(17) The role of high cholesterol in age-related COVID19 lethality.bioRxivSeptember 21, 2022Hao Wang, Zixuan Yuan, Mahmud Arif Pavel, Sonia Mediouni Jablonski, Joseph Jablonski, Robert Hobson, Susana Valente, Chakravarthy B. Reddy, Scott B. Hansen(Abcam, #ab189168), anti-Furin antibody (Abcam, #ab3467) or anti-TMPRSS2 antibody [EPR3861] (Abcam, #ab92323)) for 60 min in 5% BSA / 0.05% Triton / PBS at room temperature followed by 5 washes with 1% BSA / 0.05%

(18) Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1Frontiers in Cardiovascular MedicineSeptember 15, 2022Ji Youn Youn, Jian Wang, Qian Li, Kai Huang, Hua Caiwith antibodies for ACE2 (1:1,000, #ab15348, Abcam, Waltham, MA, United States), TMPRSS2 (1:1,000, #ab92323, Abcam, Waltham, MA, United States), NOX2 (1:250, #611414, BD Biosciences, San Jose, CA, United States),

(19) ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cellsReproductive biologySeptember 1, 2022Fernando SR, Chen X, Cheng KW, Wong BP, Qi S, Jiang L, Kodithuwakku SP, Ng EH, Yeung WS, Lee KF.Antibodies against ACE (1:50, PA5–83080, Invitrogen), ACE2 (1:100, MA5–31394, Invitrogen), TMPRSS2 (1:100, ab92323, Abcam). A positive signal was detected by 3,3′-diaminobenzidine (DakoCytomation) staining and nuclei

(20) Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care TherapyCancers (Basel)August 23, 2022Christophe Deben et al.antibody (R&D Systems, MAB933, 1:75 for 45 min), rabbit anti-human TMPRSS2 monoclonal antibody (Abcam, ab92323, 1:1000 for 30 min). and mouse anti-human FURIN (B-6) monoclonal antibody (Santa Cruz, sc-133142, 1:100

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Anti-TMPRSS2 antibody [EPR3861] from Abcam

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Anti-TMPRSS2 antibody [EPR3861] from Abcam

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