Fig 1: [18F]FLT uptake and TK-1 expression are greater in the 14-day AngII AAA model. (A) Representative coronal-view static [18F]FLT PET/CT images 80 to 90 minutes post-[18F]FLT injection. White arrows indicate abdominal aortic location (short arrow, saline control; long arrow, AAA). (B) Maximum and mean SUV analyses of abdominal aortic regions of interest on images in (A) of saline controls (n = 5), 14-day AngII AAA (n = 5), and 28-day AngII AAA (n = 3). (C) Representative transverse-view [18F]FLT PET/CT, ultrasound, and fused ultrasound-PET/CT images (short arrow, aortic lumen; long arrow, remodeling aortic wall). (D) Representative TK-1 and ß-actin western blots and quantitative analysis, optical intensity of TK-1 band/optical intensity of ß-actin band for baseline aortae (n = 3), saline control (n = 3), 14-day AngII AAA (n = 3), and 28-day AngII AAA (n = 3). ***P < 0.001, **P < 0.01, ns, not significant on one-way analysis of variance with post hoc Bonferroni-Holm correction. [18F]FLT, [18F]fluorothymidine; AngII, angiotensin II; AAA, abdominal aortic aneurysm; PET/CT, positron emission tomography/computed tomography; SUV, standardized uptake value; TK-1, thymidine kinase-1