Anti-IP3 receptor antibody ab5804 from Abcam

Product Specs
ItemAnti-IP3 receptor antibody
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab5804
Antibody TypePrimary
Quantity100 UL
ApplicationsImmunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ClonalityPolyclonal
IsotypeIgG
HostRabbit
Conjugate/TagUnconjugated
Concentration1.3 mg/ml
Research AreaNeuroscience
Gene NameITPR1
ReactivityHuman, Rat
TargetIP3 receptor

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Glucocorticoid enhances presenilin1-dependent Aβ production at ER's mitochondrial-associated membrane by downregulating Rer1 in neuronal cellsRedox biologySeptember 1, 2023Choi GE, Park JY, Park MR, Yoon JH, Han HJ.(#sc-47778) were purchased from Santa Cruz Biotechnology (Paso Robles, CA, USA). The antibodies of IP3R (#ab5804), TOMM20 (#ab56783), Aβ (#ab2539), APP (#ab32136), and Rab7 (#ab50533) were obtained from Abcam (Cambridge,

(2) Hepatic levels of S-adenosylmethionine regulate the adaptive response to fastingCell MetabolismAugust 8, 2023Alba Capelo-Diz, Sofía Lachiondo-Ortega, David Fernández-Ramos, Jorge Cañas-Martín, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Maria J. González-Rellan, Laura Mosca, Joan Blazquez-Vicens, Alberto Tinahones-Ruano, et al.RRID:AB_2120328 Phospho-Ire1α,Abcam,Cat#Ab48187; RRID:AB_873899 Ire1α,Santa Cruz,Cat#SC-390960; RRID:AB_2927490 IP3R,Abcam,Cat#ab5804; RRID:AB_305124 MATα1,In-house,N/A MATα2,Abcam,Cat#ab26174; RRID:AB_881274 PDI,Cell Signaling Technology,Cat#2446;

(3) NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C diseaseNature CommunicationsJuly 28, 2023Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simó, James S. Trimmer, Rose E. Dixon, Eamonn J. Dicksonµg/mL (Alomone Labs, Cat #ACC-005), pan-RyR 1:100 (Abcam, Cat #ab2868), IP3R 18 µg/mL (Abcam, Cat #ab5804), CaV2.1 1:200 (Alomone Labs, Cat #ACC-001), and KV2.1 pS603 1:5 (L61/14). After primary antibody incubation,

(4) Postoperative risk of IDH mutant glioma–associated seizures and their potential management with IDH mutant inhibitorsJournal of Clinical InvestigationJune 15, 2023Michael R. Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna T Webb, Kayla T Byrne, Dusten Unruh, Vineeth Thirunavu, et al.1:500), MAP2 (Abcam, ab5392; 1:1,000), GFAP (IHC: Biocare, CP040A, 1:500; immunofluorescent: Abcam, ab5804, 1:1,000), phospho-S6 (Cell Signaling, Ser235/236, 2211; 1:1,000), synaptophysin (Thermo Fisher Scientific,

(5) High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca2+ leak towards mitochondriaPLOS ONEJune 9, 2023Yves Gouriou, Fabrice Gonnot, Mariam Wehbi, Camille Brun, Ludovic Gomez, Gabriel Bidauxreduced proteins of each sample was loaded on a 6% SDS-PAGE. For the IP3R1 immunoblotting (1/500, Abcam, ab5804) (S1B Fig), a 10% SDS-PAGE gel was used and the protein transfer was performed at low intensity overnight

(6) Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer's diseaseIBRO Neurosci RepJune 1, 2023Chernyuk D, Callens M, Polozova M, Gordeev A, Chigriai M, Rakovskaya A, Ilina A, Pchitskaya E, Van den Haute C, Vervliet T, et al.(1:200 dilution, Invitrogen, cat. no. MA5–32977) and polyclonal IP3R1 (1:300 dilution, Abcam, cat. no. ab5804) was carried out for 16 h, after which there was staining with secondary antibodies Alexa-Fluor 594

(7) Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorderDiscover Mental HealthMarch 9, 2023Annie Kathuria, Kara Lopez-Lengowski, Donna McPhie, Bruce M. Cohen, Rakesh Karmacharya°C: anti-VDAC1 antibody [20B12AF2] (Abcam, ab14734, diluted 1:100) and anti-IP3R1 antibody (Abcam, ab5804, diluted 1:500) [27]. The antibodies were then removed and the cells washed with PBS + 0.01% Triton-X100.

(8) Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver GluconeogenesisNutrientsDecember 24, 2022Anaïs Alves, Frédéric Lamarche, Rémy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stéphanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, et al.situ PLA which targeted the complex between the ER inositol 1,4,5-triphosphate receptor (IP3 R)-1 (ab5804, Abcam, Paris, France) and the mitochondrial voltage-dependent anion channel (VDAC)-1 (ab14734, Abcam,

(9) PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTDActa NeuropathologicaNovember 1, 2022Federica Pilotto, Alexander Schmitz, Niran Maharjan, Rim Diab, Adolfo Odriozola, Priyanka Tripathi, Alfred Yamoah, Olivier Scheidegger, Angelina Oestmann, Cassandra N. Dennys, et al.(1:200, Abcam, ab2799), rabbit anti-GRP75 (1:200, Abcam, ab53098), rabbit anti-IP3R (1:500, Abcam, ab5804), mouse anti-VDAC1 (1:500, Millipore, MABN504), rabbit anti-GFP (1:1000, Cell Signaling, 2956), mouse

(10) Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injuryFrontiers in NeurologyOctober 20, 2022Katherine M. Fronczak, Andrea Roberts, Sarah Svirsky, Madison Parry, Erik Holets, Jeremy Henchir, C. Edward Dixon, Shaun W. Carlsonantibody (Rabbit, 1:2,000, Fujifilm Wako, Cat# 019-19741), anti-GFAP (Rabbit, 1:5,000, Millipore, Cat# AB5804), anti-synaptophysin antibody (Rabbit, 1:2000, Abcam, Cat# 32127) or Rabbit anti-neurogranin (Rabbit,

(11) Astrocyte-Derived TNF-α-Activated Platelets Promote Cerebral Ischemia/Reperfusion Injury by Regulating the RIP1/RIP3/AKT Signaling PathwayMolecular NeurobiologySeptember 1, 2022Wei Li, Dengping Liu, Jiaqi Xu, Jun Zha, Chen Wang, Jianzhong An, Zhanli Xie, Shigang Qiao(1:100, AF6990, R&D, USA), mouse anti-TNF-α (1:100, ab1793, Abcam, USA), and rabbit anti-GFAP (1:500, AB5804, Millipore, USA) antibodies. After being washed again with PBS, the sections were incubated with Alexa Fluor 488 donkey anti-sheep IgG(H + L

(12) CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disabilityPLoS biologySeptember 1, 2022Müller F, De Virgiliis F, Kong G, Zhou L, Serger E, Chadwick J, Sanchez-Vassopoulos A, Singh AK, Eswaramoorthy M, Kundu TK, et al.Promega G7121), H3K27ac (1:500, ab4729), H3K9ac (1:500, Cell Signalling 9671), GFAP (1:500, Millipore AB5804), CD68 (1:500, Abcam ab213363), vGlut1 (1:1,000, Synaptic system 135302), vGat1 (1:500, Synaptic systems

(13) Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissuesNature communicationsJune 9, 2022Wang M, Li W, Hao J, Gonzales A 3rd, Zhao Z, Flores RS, Kuang X, Mu X, Ching T, Tang G, et al.respectively. The samples were incubated with the primary antibodies of GFAP (Abcam, dilution 1:100, cat no. AB5804), TUJ1 (Abcam, dilution 1:1000, cat no. NL1195V), synaptophysin (Sigma-Aldrich, dilution 1:100, cat

(14) Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscleCell death & diseaseApril 2, 2022Lu X, Gong Y, Hu W, Mao Y, Wang T, Sun Z, Su X, Fu G, Wang Y, Lai D.anti-GRP75 mouse mAb (1:1000, Cat. sc-133137, Santa Cruz, CA, USA), anti-IP3R rabbit pAb (1:1000, Cat. ab5804, Abcam, MA, USA), anti-VDAC1 mouse mAb (1:1000, Cat. Ab186321, Abcam), anti-TOMM20 rabbit mAb (1:1000,

(15) Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's diseaseNeurobiology of AgingApril 1, 2022Martin J. Dahl, Mara Mather, Markus Werkle-Bergner, Briana L. Kennedy, Samuel Guzman, Kyle Hurth, Carol A. Miller, Yuchuan Qiao, Yonggang Shi, Helena C. Chui, et al.phosphor-tau (AT8, MN1020, Thermo Scientific, USA; 1:1000 for 15 min; GFAP Rb pAb, Chemicon, Temecula AB5804, CA, USA; 1;2500) for 15 min; (NeuN, AbCAM, ab104224, USA; 1:800) for 30m. a-Synuclein Rb pAb, Chemicon,

(16) In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in MacrophagesFrontiers in Molecular BiosciencesMarch 15, 2022Leandro Henrique de Paula Assis, Gabriel de Gabriel Dorighello, Thiago Rentz, Jane Cristina de de Souza, Aníbal Eugênio Vercesi, Helena Coutinho Franco de de Oliveiraclone 20B12AF2 (Abcam, ab14734, Cambridge, United Kingdom) and 0.65 µg/ml rabbit anti-Ip3r1 (Abcam, ab5804) antibodies overnight at 4°C. Cells were washed three times, and proximity ligation assay (PLA) was

(17) Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in MinipigsBiomedicinesMarch 14, 2022Lytvynchuk L, Ebbert A, Studenovska H, Nagymihály R, Josifovska N, Rais D, Popelka Š, Tichotová L, Nemesh Y, Čížková J, et al.5741",1:100 GFAP,pAb rabbit,"Merck Millipore, Germany, Darmstadt, rabbit polyclonal antibody, cat. No. AB5804, lot No. 2464502",1:1000 "IbaI, MicroglialMarker",mAb mouse,"Abcam, Cambridge, UK, mouse monoclonal

(18) Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contactsJournal of biomedical scienceMarch 7, 2022Jung YH, Chae CW, Choi GE, Shin HC, Lim JR, Chang HS, Park J, Cho JH, Park MR, Lee HJ, et al.TurboFect (#R0532) was purchased from Themo Scientific (Waltham, MA, USA). Ki67 (#ab16667), IP3R1 (#ab5804), and p16INK4a (#ab108349) antibodies were acquired from Abcam (Cambridge, UK). AR (#51135), p38 (#9212S),

(19) STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cellseLifeFebruary 11, 2022Krishnan V, Ali S, Gonzales AL, Thakore P, Griffin CS, Yamasaki E, Alvarado MG, Johnson MT, Trebak M, Earley S.Thermo Fisher Scientific; anti-TRPM4- (ABIN572220); https://antibodies-online.com, Limerick, PA; anti-IP3R- (ab5804), Abcam, Cambridge, UK) diluted in PBS containing 20% SEABLOCK, 1% BSA, and 0.05% Triton X-100. Cells

(20) Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimer's DiseaseJournal of Alzheimer's disease : JADJanuary 1, 2022Dentoni G, Naia L, Portal B, Leal NS, Nilsson P, Lindskog M, Ankarcrona M.1 : 1000), Mfn2 (Abcam, #Ab56889 1 : 1000), Miro (SigmaAldrich, #HPA010687 1 : 750), IP3Rs (Abcam #ab5804 1 : 500), Kif5β (Abcam, #ab167429 1 : 1000), PS1 (Chemicon, #AB5308), PS2 (Oncogene, #PC305T-UG), SNAP25

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1/31/2017Immunofluorescence Of IP3R For Proximity Ligation Assay Claire StewartThe mitochondrial associated membrane (MAM) is a well established point of communication between the ER and mitochondria. IP3R is typically found in the ER but has been identified in isolated MAM ... Read Review

Anti-IP3 receptor antibody from Abcam

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Anti-IP3 receptor antibody from Abcam

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