Anti-KCNN4 (KCa3.1, SK4) Antibody APC-064 from Alomone Labs, Ltd.

Product Specs
ItemAnti-KCNN4 (KCa3.1, SK4) Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAPC-064
Brand/TrademarkAlomone Labs Ltd
ApplicationsICC, IF, IHC, IP, WB
FormatReconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3., Lyophilized Powder
ClonalityPolyclonal
ReactivityHuman (Tested);Mouse (Tested);Rat (Tested)
HostRabbit
Quantity1 X 25 mcl, 1 X 50 mcl, 1 X 0.2 ml
Conjugate/TagUnconjugated
Antibody TypePrimary
Concentration08 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Domain/Region/TerminusIntracellular, C-terminal domain
Gene NameKCNN4
TargetKCNN4 (KCa3.1, SK4) Channel
ValidationAs per applications, See images, contact for clarifications
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

RQVRLKHRKLREQV(C), corresponding to amino acid residues 350-363 of rat KCNN4

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivoCell death & diseaseDecember 20, 2022Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad SA, Patel SH, et al.following antibodies: PMCA (1:2000 in TTBS, Thermo Fisher Scientific #MA3-914); KCa3.1 (Alomone Labs #APC-064); VDAC-1 (1:2000 in TTBS, Santa Cruz Biotechnologies (SCBT) #sc-390996); TOM-20 (1:1000 in TTBS, SCBT

(2) Effects of KCa channels on biological behavior of trophoblastsOpen Life SciencesSeptember 3, 2022Xiaolei Zhang, Meitao Yang, Dan Lv, Yin Xie, Yanan Sun, Yanling Zhang, Mengzhou He, Haiyi Liu, Fanfan Li, Dongrui DengThe primary antibodies included rabbit anti-BKCa α (APC-107, 1:100), BKCa β1 (APC-036, 1:100), IKCa (APC-064, 1:100), and SKCa (APC-025, 1:100), all of which were provided by Alomone Labs Company in Israel. They

(3) Signaling and structures underpinning conducted vasodilation in human and porcine intramyocardial coronary arteriesFrontiers in Cardiovascular MedicineAugust 12, 2022Kim A. Dora, JinHeng Lin, Lyudmyla Borysova, Timea Beleznai, Michael Taggart, Raimondo Ascione, Christopher Garlandantibodies were as follows: 1:100 rabbit polyclonal anti-rat KCa3.1 (aa 350–363; Alomone Laboratories, APC-064); 1:100 mouse monoclonal anti-human KCa3.1 (third extracellular loop; Alomone Laboratories, ALM-051);

(4) Endothelial K(Ca) 1.1 and K(Ca) 3.1 channels mediate rat intrarenal artery endothelium-derived hyperpolarization responseActa physiologica (Oxford, England)April 1, 2021Pinilla E, Sánchez A, Martínez MP, Muñoz M, García-Sacristán A, Köhler R, Prieto D, Rivera L.

(5) PD1 blockade enhances K⁺ channel activity, Ca²⁺ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancerJournal for immunotherapy of cancerOctober 1, 2020Newton HS, Gawali VS, Chimote AA, Lehn MA, Palackdharry SM, Hinrichs BH, Jandarov R, Hildeman D, Janssen EM, Wise-Draper TM, et al.

(6) Metabolic regulation of endothelial SK channels and human coronary microvascular functionInternational journal of cardiologyAugust 1, 2020Liu Y, Kabakov AY, Xie A, Shi G, Singh AK, Sodha NR, Ehsan A, Usheva A, Agbortoko V, Koren G, et al.

(7) Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral ArteriesCellsApril 8, 2020Manuel Lasch, Amelia Caballero Martinez, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Sarah Meister, Elisabeth Deindlwere stained with a rabbit anti-KV1.3 (catalog number APC-101) or a rabbit anti-KCa3.1 (catalog number APC-064) antibody (both from Alomone Labs) followed by a goat anti-rabbit IgG Alexa fluor 488-conjugated antibody

(8) Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's diseaseAnnals of clinical and translational neurologyApril 1, 2019Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I.amyloid plaques, 400 nmol/L FSB (Sigma) was used. To detect mouse KCa3.1, the following antibodies were used: APC064 (1:3000, Alomone Labs), P4997 (1:3000, Sigma), AV35098 (1:3000, Sigma), and SC‐365265 (1:3000, Santa Cruz

(9) Histone Deacetylases Enhance Ca(2+)-Activated K⁺ Channel K(Ca)3.1 Expression in Murine Inflammatory CD4⁺ T CellsInternational journal of molecular sciencesSeptember 27, 2018Matsui M, Terasawa K, Kajikuri J, Kito H, Endo K, Jaikhan P, Suzuki T, Ohya S.

(10) Increased myoendothelial feedback is associated with increased connexin37 and IK 1 channel expression in mesenteric arteries of diet‐induced hyperhomocysteinemic miceMicrocirculationNovember 1, 2017Robin C. Looft‐Wilson, Cara R. Goodell, Christina A. Mutch, Stephanie M. Mutchler, Kayla L. Miller, Monique Guraya#CX37A11-A; 1:1428, Abcam, Cambridge, MA, #ab58918) and IK1 (1:1000, Alomone Labs, Jerusalem, Israel, #APC-064) were detected using a near-infrared secondary antibody (1:20,000; Li-Cor, IRDye 680RD Gt Anti-Rabbit

(11) IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell linesOncotargetJune 27, 2017Thurber AE, Nelson M, Frost CL, Levin M, Brackenbury WJ, Kaplan DL.

(12) Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca ²⁺ -Activated K ⁺ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in HypertensionHypertensionJanuary 1, 2017Takunori Seki, Kenichi Goto, Kanako Kiyohara, Yasuo Kansui, Noboru Murakami, Yoshie Haga, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari KitazonoAlomone Laboratories, Jerusalem, Israel), anti-SKCa (APC-025; batches AN1002, 1102; Alomone Laboratories), anti-IKCa (APC-064; batch Seki et al Downregulation of TRPV4 Channel in Hypertension 145 AN0402; Alomone Laboratories),

(13) Human neuronal changes in brain edema and increased intracranial pressureActa neuropathologica communicationsAugust 4, 2016Faragó N, Kocsis ÁK, Braskó C, Lovas S, Rózsa M, Baka J, Kovács B, Mikite K, Szemenyei V, Molnár G, et al.20 for 2 h at room temperature. The tissue sections were incubated with Rabbit-KCNN4 1:300 (Alomone, APC-064) or Rabbit-KCNN4 1:100 (Thermo PA5-33875) primary antibody diluted in tris-buffered saline, 2 days at

(14) Investigating CFTR and KCa3.1 Protein/Protein InteractionsPloS oneJanuary 1, 2016Klein H, Abu-Arish A, Trinh NT, Luo Y, Wiseman PW, Hanrahan JW, Brochiero E, Sauvé R.

(15) Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer CellsPloS oneJanuary 1, 2016Zhang P, Yang X, Yin Q, Yi J, Shen W, Zhao L, Zhu Z, Liu J.

(16) Complementary roles of KCa3.1 channels and β1-integrin during alveolar epithelial repairRespiratory researchSeptember 4, 2015Girault A, Chebli J, Privé A, Trinh NT, Maillé E, Grygorczyk R, Brochiero E.suspension. The precleared soluble lysates were then incubated for 1–2 h with a rabbit anti-KCa3.1 antibody (APC-064, Alomone Labs, Jerusalem, Israel) [43] or a mouse anti-β1-integrin antibody (610467, BD Biosciences,

(17) AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertensionScience signalingJuly 8, 2014Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.polyclonal antibody specific for AKAP150 (sc-6445, 1:250; Santa Cruz Biotechnology Inc.), IK channels (APC-064, 1:500; Alomone Labs), or PKCα (sc-208; Santa Cruz Biotechnology Inc.) overnight at 4°C. After five

(18) Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker ratsPloS oneJanuary 1, 2014Climent B, Moreno L, Martínez P, Contreras C, Sánchez A, Pérez-Vizcaíno F, García-Sacristán A, Rivera L, Prieto D.

(19) Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexesBritish Journal of PharmacologyAugust 1, 2013Ramesh Chennupati, Wouter H Lamers, S Eleonore Koehler, Jo G R De Mey[anti-KCa 3.1, 1:600 in normal goat serum (NGS); Alomone Labs (Jerusalem, Israel); product number: APC-064; Lot number: AN-02] and horseradish peroxidase-coupled rabbit antibodies against sheep IgG (1:400 in

(20) Characterisation of K+ channels in human fetoplacental vascular smooth muscle cellsPloS oneJanuary 1, 2013Brereton MF, Wareing M, Jones RL, Greenwood SL.chorionic plate arterial SMCs Expression of BKCa (10 µg/ml; APC-107 Alomone Labs) and IKCa (8 µg/ml; APC-064 Alomone Labs) was assessed in CPASMCs by immunocytochemistry and confirmed in CPA sections. K+ channel

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