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Anti-TopBP1 antibody
Anti-TopBP1 antibody from Abcam
Be the first to write a review!
Citations:
(37)
Supplier Page
Supplier Page from
Abcam for
Anti-TopBP1 antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-TopBP1 antibody
Company
Abcam
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
ab2402
Antibody Type
Primary
Quantity
50 UL
Applications
Western blot
Isotype
IgG
Host
Rabbit
Clonality
Polyclonal
Conjugate/Tag
Unconjugated
Format
Antibody was affinity purified using the peptide immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG
Concentration
1 mg/ml
Gene Name
TOPBP1
Reactivity
Human, Mouse
Target
TopBP1
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (37)
(1)
Mitotic tethering enables inheritance of shattered micronuclear chromosomes
Nature
June 1, 2023
Trivedi P, Steele CD, Au FKC, Alexandrov LB, Cleveland DW.
(
Cell Signaling Technologies
,
2577
,
1:1000
IF), anti-
TOPBP1
(
Bethyl Laboratories
,
A300–111A
,
1:2000
IF,
1:2000
IB) (
Abcam
,
ab2402
,
1:1000
IF), anti-MDC1 (
Abcam
ab11171
,
1:1000
IF,
1:1000
IB),
anti-CIP2A
(
clone
2G10–3B5;
Santa Cruz
(2)
The Role of ATR Inhibitors in Ovarian Cancer: Investigating Predictive Biomarkers of Response
Cells
August 1, 2022
Alice Bradbury, Frank T. Zenke, Nicola J. Curtin, Yvette Drew
(
Santa Cruz
,
Sc8349
;
1:1000
), PARP1 (
Biovision
, Milpitas, CA, USA,
3001-100
;
1:500
), TopBP1 (
Abcam
,
Ab2402
;
1:1000
) and XRCC1 (
Santa Cruz
,
Sc56254
;
1:500
). HRP conjugated secondary antibodies (Agilent Dako,
(3)
The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Nature communications
July 16, 2022
De Marco Zompit M, Esteban MT, Mooser C, Adam S, Rossi SE, Jeanrenaud A, Leimbacher PA, Fink D, Shorrocks AK, Blackford AN,
et al
.
custom-made,
1:500
)11, MDC1 pSer196 (Rabbit, 21st Century, custom-made
1:200
)11, TOPBP1 (Rabbit,
Abcam
,
ab2402
,
1:1500
),
CIP2A
(Rabbit,
Cell Signaling
,
14805
,
1:1000
),
CIP2A
(
Mouse
,
Santa Cruz
,
sc-80659
,
1:1000
),
(4)
The CDK1-TOPBP1-PLK1 axis regulates the Bloom’s syndrome helicase BLM to suppress crossover recombination in somatic cells
Science Advances
February 4, 2022
Chiara Balbo Pogliano et al.
anti–FLAG-HRP (
A8592
-1MG,
Sigma-Aldrich
), rabbit anti-FLAG (
F7425
,
Sigma-Aldrich
), rabbit anti-TOPBP1 (
ab2402
,
Abcam
), rabbit anti-TOPBP1 (D8G4L, Cell Signaling Technology), and rabbit anti-KU70 (
ab92450
,
Abcam
). High-content
(5)
SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions
The Journal of cell biology
January 4, 2021
Ishimoto R, Tsuzuki Y, Matsumura T, Kurashige S, Enokitani K, Narimatsu K, Higa M, Sugimoto N, Yoshida K, Fujita M.
sc1887
),
ATRIP
(
Cell Signaling
; Rabbit, #
2737
), RPA34 (Calbiochem;
Mouse
, NA19L), TOPBP1 (
Abcam
; Rabbit,
ab2402
),
FANCD2
(
Novus
; Rabbit,
NB100-182
), LacI (
clone
9A5,
Merck
,
Mouse
, #
05-503
), HA (
clone
3F10;
Roche
;
(6)
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
Nature communications
September 24, 2020
Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M,
et al
.
Antibody,Source,Catalog number,Dilution 1. ATR,Cell Signal,2790,
1 : 1000
(WB);
1 : 100
(IF) 2. TopBP1,
Abcam
,
ab2402
,
1 : 1000
(WB) 3. Nup133,SantaCruz,sc-27392,
1 : 500
(WB) 4. Tubulin,
Sigma
,
T5168
,
1 : 5000
(WB) 5. Lamin
(7)
A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation
Nucleic acids research
August 20, 2020
Guarino Almeida E, Renaudin X, Venkitaraman AR.
(
Invitrogen
33-1700
),
POLD1
(
Santa Cruz
Biotecnology,
sc-17776
),
SLD5
(
Abcam
,
ab121874
), TOPBP1 (
Abcam
,
ab2402
) or WDHD1 (
Abcam
,
ab72436
). Secondary HRP-conjugated antibodies were used and the signal was detected
(8)
Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway
Aging (Albany NY)
May 27, 2020
Kaiwen Li et al.
tissue slides were incubated with the primary antibody against TopBP1 (rabbit polyclonal antibody,
ab2402
,
Abcam
Co. Ltd., UK) at a dilution of
1: 100
, overnight at 4°C. Following washed with PBS, peroxidase
(9)
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Nature communications
January 8, 2020
Mooser C, Symeonidou IE, Leimbacher PA, Ribeiro A, Shorrocks AK, Jungmichel S, Larsen SC, Knechtle K, Jasrotia A, Zurbriggen D,
et al
.
GeneTex
,
GTX70224
, 1/1000),
TOPBP1
(
A300-111A
,
Bethyl Laboratories
, 1/5000),
TOPBP1
(rabbit,
Abcam
,
Ab2402
, 1/1500), ATM pS1981 (rabbit, Epitomics, 2152-1, 1/5000), ATM (rabbit, Calbiochem, PC-116, 2/250),
Treacle
(10)
Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions
The Journal of cell biology
September 2, 2019
Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M.
(
1:500
; rabbit;
ab122245
;
Abcam
),
DDB1
(
1:2,000
; rabbit;
ab109027
;
Abcam
), TOPBP1 (
1:1,000
; rabbit;
ab2402
;
Abcam
),
RPA32
phospho S4/8 (
1:500
; rabbit;
A300-245A
;
Bethyl
),
KAP1
phospho S824 (
1:500
; rabbit;
ab70369
;
(11)
Dicer prevents genome instability in response to replication stress
Oncotarget
July 8, 2019
Fragkos M, Barra V, Egger T, Bordignon B, Lemacon D, Naim V, Coquelle A.
#
GTX128145
), anti-FANCD2 (
Santa Cruz
, #
sc-20012
), anti-FANCD2 (Novus, #NB-100-182), anti-TopBP1 (
Abcam
, #
ab2402
), anti-Vinculin (
Abcam
, #
ab180581
),
anti-Lamin A
/C (
Santa Cruz
, #
sc-7292
), anti-
RPA2
(Calbiochem, #NA18),
(12)
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
Molecular cell
May 2, 2019
Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D,
et al
.
Bethyl Laboratories
, 1/1000), SMC1 (
ab9262
,
Abcam
, 1/5000), SMC1-pS966 (
ab1267
,
Abcam
, 1/2500),
TOPBP1
(
ab2402
,
Abcam
, 1/1500). To generate the MDC1-pS168 affinity purified rabbit polyclonal antibody, the synthetic
(13)
A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
EBioMedicine
March 1, 2019
Wu M, Wang Y, Yang D, Gong Y, Rao F, Liu R, Danna Y, Li J, Fan J, Chen J,
et al
.
Cell Signaling
Cytochrome C (
ab13575
), GSMDE (
ab215191
), CDC25C (
ab32444
),
GSDMD
(
ab219800
), TOPBP1 (
ab2402
),
RAD51
(
ab133534
) and 53BP1 (
ab36823
) antibodies were purchased from
Abcam
(United Kingdom). 2.4
Flow cytometry analysis
(14)
RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling
Nucleic Acids Research
January 25, 2019
Rakesh Deshar, Wonjin Yoo, Eun-Bee Cho, Sungjoo Kim, Jong-Bok Yoon
Santa Cruz Biotechnology
; anti-phospho H2AX S139 (#
ab11174
,
1:20000
), anti-H2AX (#
ab11175
,
1:10 000
) and anti-TOPBP1 (#
ab2402
,
1:5000
) from
Abcam
; anti-phospho CHK1 S345 (#
2348
,
1:2500
), anti-
CHK1
(#sc-8408,
1:3000
) and anti-MYC
(15)
53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress
Molecular and cellular biology
April 15, 2018
Her J, Ray C, Altshuler J, Zheng H, Bunting SF.
antibodies used were antibodies to
RPA32
(CST;
2208S
),
53BP1
(Novus;
NB100-304
), and TopBP1 (
Abcam
;
ab2402
). After the binding of secondary antibody,
EdU
-positive cells were labeled with the Click-iT EdU Alexa
(16)
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
Nature communications
March 6, 2018
Hernández G, Ramírez MJ, Minguillón J, Quiles P, Ruiz de Garibay G, Aza-Carmona M, Bogliolo M, Pujol R, Prados-Carvajal R, Fernández J,
et al
.
anti-ORC2 (
ab31930
,
Abcam
)
1:1000
, rabbit anti-RAD51 (8349, Santa Cruz)
1:250
, rabbit anti-TOPBP1 (
ab2402
,
Abcam
)
1:1000
,
mouse
anti-vinculin (
ab18058
,
Abcam
)
1:5000
,
goat
anti-rabbit-Alexa 568 conjugated (
A11036
,
(17)
Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer
Clinical Cancer Research
February 1, 2018
Wei Zhang et al.
against
N-MYC
(
Abcam
,
ab16898
),
PARP1
(
Santa Cruz
,
sc-8007
), PARP2 (
Abcam
,
ab176330
), TOPBP1 (
Abcam
,
ab2402
), BRCA1 (
Cell Signaling Technology
,
9025S
), POLE (
Santa Cruz
,
sc-135885
),
RMI2
(
Abcam
,
ab122685
). Washed
(18)
p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
PLoS Genetics
June 15, 2017
Marina Marcet-Ortega, Sarai Pacheco, Ana Martínez-Marchal, Helena Castillo, Elsa Flores, Maria Jasin, Scott Keeney, Ignasi Roig
(19)
Targeting DNA damage response in prostate cancer through inhibition of androgen receptor/CDC6-ATR-Chk1 signaling
Cell Reports
February 15, 2017
Styliani Karanika et al.
Cell Signaling Technology
. Antibodies against P-
CDC6
Ser54 (
ab75809
), P-Chk1ser296 (
ab79758
), and
TopBp1
(
ab2402
) were purchased from
Abcam
. Antibodies against GAPDH (365062) and AR (816) were purchased from Santa
(20)
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
The Journal of cell biology
February 1, 2016
Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M,
et al
.
constructs were verified by
sequencing
. Antibodies We used the following rabbit antibodies: TOPBP1 (
ab2402
;
Abcam
), RAD51 (
sc8349
;
Santa Cruz
;
ab63801
;
Abcam
), pRAD51 S14 (Yata et al., 2012), cyclin A (NCL-CYCLINA;
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Anti-TopBP1 antibody from Abcam
Supplier Page
View Company Product Page
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