Fig 1: The concentration of serum proinflammatory cytokines among the groups of rats. sCD14: soluble CD14; precepsin; HMGB-1: high mobility group box-1; IL-10: interleukin 10; TNF-a: tumor necrosis factor alpha; IL-1a: interleukin 1 alpha; IL-6: interleukin 6. (a) The serum sCD14 concentration (ng/mL) among different groups; it is a marker of inflammation in the late stage of sepsis. (c) Serum concentration of IL-10, TNF-a, IL-1a, and IL-6 (pg/mL) among groups. The serum sCD14 levels of the model group, GTS-21 group, and MLA group were much higher than those of the control group. The P value and 95% CI were, respectively, 0.000, -286.858~-79.4662; 0.44, -209.616~-2.223; and 0.000, 400.647~-193.255, and so were HMGB1, TNF-a, IL-10, and IL-6. For HMGB1, they were 0.000, -766.215~-289.627; 0.012, -527.403~-50.815; and 0.000, -917.862~-441.275. For TNF-a, they were 0.000, -139.923~-82.198; 0.000, -104.224~-46.494; and 0.000, 175.466. For IL-1a, they were 0.000, -102.305~-57.714; 0.000, -66.369~-21.777; and 0.000, -121.697~-77.106. For IL-10, they were 0.000, -83.572~-32.005; 0.006, -59.758~-8.191; and 0.000, -108.319~-56.752. For IL-6, they were 0.000, -77.851~-42.647; 0.000-59.996~-24.792; and 0.000, -87.186~-51.982. The serum sCD14, HMGB1, TNF-a, IL-1a, IL-10, and IL-6 levels of the MLA group were much higher than those of rats in the GTS-21 group; the P value and 95% CI were, respectively, 0.000, -294.727~-87.3357; 0.001, 152.166~628.754; 0.000, 42.107~99.837; 0.000, 33.033~77.624; 0.000, 22.777~74.344; and 0.001, 9.588~44.792. A: P < 0.05 vs. control group; B: P < 0.05 vs. model group; C: P < 0.05 vs. GTS-21 group.