Fig 1: Over-expression of IKKß promotes secretions of TAT, TM, PIIIP and PAI-1, and inhibits ATIII production, while low-expression has inverse effects on these molecules from LPS-stimulated AEC II. Bar graphs of concentrations about the indicators above as assessed by enzyme-linked immunosorbent assays in cell-supernatant of each group. Values are presented as the mean ± standard deviation; aP<0.05 vs. the ctrl, bP<0.05 vs. the LPS group as determined by one-way analysis of variance. TAT, thrombin-antithrombin; ATIII, antithrombin III; TM, thrombomodulin; PIIIP, procollagen III N terminal peptide; ctrl, control; AEC II, alveolar epithelial cell type II; LPS, lipopolysaccharide; NC, negative control; sh, short hairpin.