Fig 1: Validation of selected candidate proteins by ELISA analysis. a Correlation between PRM-MS and ELISA assay results for PZP. b Differential expression of PZP in the T2DM + LAC and T2DM groups in the discovery set. c Differential expression of PZP in the T2DM + LAC and T2DM groups in the validation set. d Differential expression of PZP in the T2DM + LAC and T2DM groups in the whole set. e ROC analysis of the diagnostic value of PZP for the detection of LAC in T2DM patients in the whole set
Fig 2: Diagnostic value of PZP and combined diagnostic analysis. (A) Serum levels of PZP in the T2DM and T2DM + CRC groups. Unpaired t-test was used to compare the potential difference. (B) ROC analysis of the diagnostic values of PZP, CA199, CEA and the combined score.
Fig 3: Validation of selected candidate proteins by PRM-MS analysis. Differential expression of (a) PZP and (c) IGFBP3 in the T2DM + LAC and T2DM groups. ROC analysis of the diagnostic value of (b) PZP and (d) IGFBP3 for the detection of LAC in T2DM patients
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