CAY10566 from Cayman Chemical

Product Specs
ItemCAY10566
CompanyCayman Chemical
Price $204.00Supplier Page View Company Product Page
Catalog Number10012562
Research AreaEndocrinology & Metabolism
FormatA crystalline solid
Molecular Weight389.8
Purity≥98%
Storage-20
FormulaC18H17ClFN5O2
OriginUSA
TypeInhibitors
Quantity5 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 4.5 nM for SCD1 in murine enzymatic assays
IC50: 26 nM for SCD1 in human enzymatic assays 26
IC50: 7.9 nM for the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells when heptadecanoic acid is used as the substrate
IC50: 6.8 nM for the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells when palmitic acid is used as the substrate.

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Protein S -acylation dynamics provide metabolic plasticity to acute myeloid leukemia cellsbioRxivMarch 3, 2026Nithya Balasundaram, Ayşegül Erdem, Azeem Sharda, Veerle W. Daniels, Phillip L. Chea, Fleur Leguay, Youzhong Liu, Mark A. Keibler, Charles Vidoudez, Andrew A. Lane, et al.hemihydrochloride,Sigma-Aldrich,C13408 Antimycin A,Sigma-Aldrich,A8674 BPTES,Sigma-Aldrich,SML0601 CAY10566,Cayman Chemical,10012562 CB-839,Cayman Chemical,22038 Compound 968,Cayman Chemical,17199 Dichloroacetic acid,Sigma-Aldrich,D54702 Dimethyl sulfoxide

(2) Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytesMolecular metabolismMay 1, 2024Mori H, Peterson SK, Simmermon RC, Overmyer KA, Nishii A, Paulsson E, Li Z, Jen A, Uranga RM, Maung JN, et al.proteins" A-939572,Cayman Chemical,19123 bafilomycin A1,Cayman Chemical,11038 CAY10566,Cayman Chemical,10012562 Ferrostatin-1,Cayman Chemical,17729 GSK872,Cayman Chemical,23300 Liproxstatin,Cayman Chemical,17730 MF-438,Millipore

(3) FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replicationCell chemical biologyMay 19, 2022Yamane D, Hayashi Y, Matsumoto M, Nakanishi H, Imagawa H, Kohara M, Lemon SM, Ichi I.et al., 2013",N/A "Chemicals, peptides, and recombinant proteins",, CAY10566,Cayman Chemical,Cat#10012562 Mead acid,Cayman Chemical,Cat#90190 Dihomo-γ-linolenic acid,Cayman Chemical,Cat#90230 Erastin,Cayman Chemical

(4) Patient-derived three-dimensional cortical neurospheres to model Parkinson's diseasePloS oneJanuary 1, 2022Raja WK, Neves E, Burke C, Jiang X, Xu P, Rhodes KJ, Khurana V, Scannevin RH, Chung CY.patient-derived and isogenic control lines were treated with 0.3 uM CAY10566 (Cayman Chemicals, Cat. No. 10012562) along with DMSO as a vehicle. The final concentration of DMSO in the media was 0.03%. The spheres were

(5) Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesisProceedings of the National Academy of Sciences of the United States of AmericaDecember 8, 2020Yi J, Zhu J, Wu J, Thompson CB, Jiang X.(17729, Caymen), MK-2206 (S1078, Selleck Chemicals), GDC-0941 (S1065, Selleck Chemicals), CAY10566(10012562, Cayman Chemicals), Fatostatin A (4444, Tocris), SYTOX green (S7020, Thermo Fisher), propidium iodide

(6) Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cellsNature communicationsSeptember 24, 2020Du J, Su Y, Qian C, Yuan D, Miao K, Lee D, Ng AHC, Wijker RS, Ribas A, Levine RD, et al.kit (Lonza, LT07-118). Cerulenin (Sigma, C2389-5MG), TVB 3166 (Sigma, SML1694-5MG), CAY10566 (Cayman, 10012562), SC 26196 (Cayman, 10792) were dissolved in DMSO (ATCC, 4-X) at designated concentrations before adding

(7) Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic PlasticityMolecular cellJanuary 2, 2020Vivas-García Y, Falletta P, Liebing J, Louphrasitthiphol P, Feng Y, Chauhan J, Scott DA, Glodde N, Chocarro-Calvo A, Bonham S, et al.Proteins",, SCD1 inhibitor A939572,BioVision,"Cat#1716–1,5" SCD1 inhibitor CAY10566,Cayman Chemical,Cat#10012562 Salubrinal,Calbiochem,Cat#324897–5MG TNFα,GIBCO,Cat# PHC3016 Doxycycline,Sigma,Cat#D9891–10G Glutamax

(8) Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell StateCell chemical biologyMarch 21, 2019Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, et al.(Cat# 10007290), palmitelaidic acid (Cat# 9001798), oleic acid-alkyne (Cat# 9002078), CAY10566 (Cat# 10012562), triacsin C (Cat# 10007448) and deferoxamine mesylate (Cat# 14595) were from Cayman Chemical (Ann Arbor,

(9) BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cellsRedox biologyOctober 1, 2017Lee HJ, Jung YH, Choi GE, Ko SH, Lee SJ, Lee SH, Han HJ.(PI, cat no. P3566) were purchased from Life Technologies (Gaithersburg, MD, USA). CAY10566 (cat no. 10012562) was obtained from Cayman chemical (Ann Arbor, MI, USA). Cerulenin (cat no. C2389), 4-phenyl butyric

(10) Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a productionOncogenesisJune 1, 2015Wang W, Snyder N, Worth AJ, Blair IA, Witze ES.(Franklin Lakes, NJ, USA). FASN inhibitor, Cerulenin (C2389), was from Sigma. SCD inhibitor, CAY10566 (10012562), was from Cayman Chemical (Ann Arbor, MI, USA). Mov10 shRNA and expression vectors The coding sequences

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CAY10566

CAY10566

CAY10566 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

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CAY10566 from Cayman Chemical

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