(−)-Nutlin-3 from Cayman Chemical

Product Specs
Item(−)-Nutlin-3
CompanyCayman Chemical
Price $103.00Supplier Page View Company Product Page
Catalog Number18585
Quantity1 mg
Research AreaApoptosis, Cancer, Cell Death, Cell Signaling, p53, p53 Signaling, Transcription Factors
FormatA crystalline solid
Molecular Weight581.5
Purity≥98%
Storage-20
FormulaC30H30Cl2N4O4
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis networkMolecular CellJanuary 22, 2026Stephanie Halim, Rebecca M. Sebastian, Kristi E. Liivak, Jessica E. Patrick, Tiffani Hui, David R. Amici, Andrew O. Giacomelli, Paulina Rios, Vincent L. Butty, William C. Hahn, et al.ALX-380-013 STA-9090,MedChem Express,Cat# HY-15205 Puromycin,Gibco,Cat# A1113803 Nutlin-3,Cayman Chemical Company,Cat# 18585 VER-155008,Med-Chem Express,Cat# HY-10941 Deposited data,Deposited data,Deposited data Next generation sequencing

(2) Protocol for generating liver organoids containing Kupffer cells using human iPSCsSTAR ProtocOctober 10, 2025Yang Li, Yunzhong Nie, Hideki Taniguchi331752-47-7 iMatrix-511 silk,Matrixome,Cat# 892021 "Activin A solution, human, recombinant",Nacalai Tesque,Cat# 18585-81 CHIR99021,Cayman Chemical Company,Cat# 13122 Sodium butyrate (NaB),Sigma,Cat# B5887 Dimethyl sulfoxide (DMSO

(3) Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphomaNat CommunAugust 21, 2025Margaret A. Potts, Shinsuke Mizutani, Yexuan Deng, Srimayee Vaidyanathan, Keziah E. Ting, Göknur Giner, Shruti Sridhar, Girija Shenoy, Yang Liao, Sarah T. Diepstraten, et al.(Cell Signaling Technology, 9904), torin1 (Cell Signaling Technology, 14379), nutlin-3a (Cayman Chemical, 18585), etoposide (Ebewe Pharmaceuticals Ltd, A-4866) or the MCL-1 inhibitor S63845 (Active Biochem, 6044)

(4) Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cellsCell Rep MethodsDecember 16, 2024Takahashi J, Sugihara HY, Kato S, Kawasaki S, Nagata S, Okamoto R, Mizutani T.IGF-1,BioLegend,Cat#590906 Nicotinamide,Sigma,Cat#N0636 Afamin/Wnt3a conditioned medium,MBL lifescience,Cat#J2-001 Activin A,Nacalai Tesque,Cat#18585-81 CHIR99021,Cayman Chemicals,Cat#13122 Recombinant human FGF4,Peprotech,Cat#100-31 Recombinant human BMP-4

(5) qTAG: an adaptable plasmid scaffold for CRISPR-based endogenous taggingThe EMBO JournalDecember 12, 2024Reuben Philip, Amit Sharma, Laura Matellan, Anna C Erpf, Wen-Hsin Hsu, Johnny M Tkach, Haley D M Wyatt, Laurence Pelletier(sc-515784, Santa Cruz), and CEP135 (produced in-house). For the selectable knock-out experiments, Nutlin-3a (18585, Cayman Chemical) was used at 10 μM to induce TP53 accumulation in cells for detection. For fixed imaging,

(6) Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasmsNature CommunicationsJuly 17, 2024Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, et al.loss of p53 function, TP53-targeted cells were treated with 1000 μM nutlin-3a (Cayman Chemical, Cat# 18585) for four days and assessed for an increase in KO score (Supplementary Fig. 9d) in two independent experiments

(7) Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibitioneLifeApril 29, 2024Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, et al.drug",Cycloheximide,Sigma,Cat# C4859-1ML, "Chemical compound, drug",Nutlin-3a,Cayman Chemical Company,Cat# 18585, "Chemical compound, drug",Rapamycin,MedChem Express,Cat# HY-10219, "Chemical compound, drug",Pinometostat,Cayman Chemical Company

(8) Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responsesCell Death & DifferentiationFebruary 1, 2024John E. La Marca, Brandon J. Aubrey, Bruce Yang, Catherine Chang, Zilu Wang, Andrew Kueh, Lin Tai, Stephen Wilcox, Liz Milla, Susanne Heinzel, et al.into T125 flasks in quadruplicate, and each replicate treated with nutlin-3a (10 μM, Cayman Chemical #18585) or DMSO (vehicle control; Sigma-Aldrich #D4540) for 24 h. From the treated samples, the remaining live

(9) Protocol to generate large human intestinal organoids using a rotating bioreactorSTAR ProtocolsSeptember 1, 2023Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro MizutaniFisher,Cat#17502-048 "B-27 Supplement (50×), serum free",Thermo Fisher,Cat#17504-044 Activin A,Nacalai Tesque,Cat#18585-81 CHIR99021,Cayman Chemicals,Cat#13122 Recombinant human FGF4,PeproTech,Cat#100-31 Y-27632,Fujifilm

(10) Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugsCell Death & DifferentiationApril 1, 2023Sarah T. Diepstraten, Savannah Young, John E. La Marca, Zilu Wang, Ruth M. Kluck, Andreas Strasser, Gemma L. KellyAustralia), doxorubicin (Ebewe Interpharma), vincristine (Sigma-Aldrich #V8879), Nutlin-3a (Cayman Chemicals #18585) and 5’azacytidine (Sigma-Aldrich #A2385). Cells were incubated with the drugs at 37 °C for 24 h. Plates

(11) Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoidsCell Rep MethodsNovember 21, 2022Takahashi J, Mizutani T, Sugihara HY, Nagata S, Kato S, Hiraguri Y, Takeoka S, Tsuchiya M, Kuno R, Kakinuma S, et al.,Thermo Fisher,Cat#17502-048 "B-27 Supplement (50X), serum free",Thermo Fisher,Cat#17504-044 Activin A,Nacalai Tesque,Cat#18585-81 CHIR99021,Cayman Chemicals,Cat#13122 Recombinant human FGF4,Peprotech,Cat#100-31 Y-27632,Fujifilm

(12) HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZPharmaceuticals (Basel, Switzerland)August 17, 2022Miyajima C, Hayakawa Y, Inoue Y, Nagasaka M, Hayashi H.actinomycin D. 4. Materials and Methods 4.1. Materials Simavastatin (10010344) and (-)-nutlin-3 (18585) were purchased from Cayman Chemicals (Ann Arbor, MI, USA). Fluvastatin (068-06641) was purchased from

(13) Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent MannerCancer ResearchOctober 17, 2021James I. McDonald et al.treated with 500 nM AZA (Sigma-Aldrich) or PBS for three days and 10 uM Nutlin-3A (Cayman Chemical 18585) or DMSO for 6 hours. RT-qPCR 1 ug of RNA was treated with DNaseI (Thermo #EN0525) for 30 min at 37

(14) ZNF768 links oncogenic RAS to cellular senescenceNature communicationsAugust 17, 2021Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, et al.(Cayman Chemical, #10012628), Doxycycline (Sigma, #D3447), Doxorubicin (Tocris, #2252), Nutlin3a (Cayman Chemical, #18585) and Rapamycin (LC Laboratories, #R5000). Virus production and infection Retroviruses were produced

(15) A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathiesDevelopmental cellJuly 26, 2021Tiu GC, Kerr CH, Forester CM, Krishnarao PS, Rosenblatt HD, Raj N, Lantz TC, Zhulyn O, Bowen ME, Shokat L, et al.324517 "Dimethyl sulfoxide (DMSO, cell culture grade)",Sigma,Cat# D2650 Nutlin-3a,Cayman Chemicals,Cat#18585 Doxorubicin hydrochloride,Sigma,Cat# D1515 TURBO DNase,Ambion,Cat# AM2238 SUPERase In RNase Inhibitor,Ambion,Cat#

(16) Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancerCell death and differentiationFebruary 1, 2020Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, et al.six-well plates, and left either treated with 0.1% DMSO (vehicle) or Nutlin-3 (10 μM, Cayman Chemicals Cat#18585) for 72 h. Cells were harvested, and prepared for Immunoblot or Real-time PCR analysis. Human subjects Data

(17) PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growthNature communicationsDecember 20, 2019Cai W, Su L, Liao L, Liu ZZ, Langbein L, Dulaimi E, Testa JR, Uzzo RG, Zhong Z, Jiang W, et al.bleomycin (9041–93–4) and trichostatin A (TSA, S1045) were purchased from Selleck Chemical. Nutlin-3a (18585) was purchased from Cayman Chemical. Propidium iodide (PI, P3566) was purchased from Life Technologies.

(18) Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor developmentGenes & DevelopmentNovember 1, 2018Brandon J. Aubrey et al.and treated with drugs in tissue culture medium. Nutlin-3a stock solution in DMSO [Cayman chemical, 18585; synonym: (-)-nutlin-3], docetaxel solution (Sandoz), and 20 mg/mL Etoposide solution (Pfizer, 503289)

(19) Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder CancerCellApril 5, 2018Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, Chua CW, Barlow LJ, Kandoth C, Williams AB, et al.,Cayman Chemical,Cat#13596 "FK866 (APO866, Daporinad)",Selleck Chemicals,Cat#S2799 Nutlin-3a,Cayman Chemical,Cat#18585 Avagacestat (BMS-708163),Cayman Chemical,Cat#16711 Tanespimycin (17-AAG),Cayman Chemical,Cat#11039 Ganetespib,Selleck Chemicals

(20) Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c⁺CD103⁺ Monocytic Antigen-Presenting Cells in TumorsImmunityJanuary 16, 2018Sharma MD, Rodriguez PC, Koehn BH, Baban B, Cui Y, Guo G, Shimoda M, Pacholczyk R, Shi H, Lee EJ, et al.(#1801-5). Whole OVA protein (#A-5503) and N-acetyl-L-cysteine (#A-7250) were from Sigma. Nutlin-3a (#18585) was from Cayman Chemical. Indoximod (1-methyl-D-tryptophan, clinical grade) was obtained from NewLink

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(−)-Nutlin-3 from Cayman Chemical

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Cayman Chemical

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(−)-Nutlin-3 from Cayman Chemical

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