FCCP from Cayman Chemical

Product Specs
ItemFCCP
CompanyCayman Chemical
Price $278.00Supplier Page View Company Product Page
Catalog Number15218
Quantity50 mg
Research AreaCell Biology, Cytoskeleton & Motor Proteins, Mitochondrial Biology
FormatA crystalline solid
Molecular Weight254.2
Purity≥98%
Storage-20
FormulaC10H5F3N4O
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Specialized high-capacity mitochondria fuel cell invasionCurr BiolApril 20, 2026Isabel W. Kenny-Ganzert, Lena P. Basta, Lianzijun Wang, Qiuyi Chi, Laura C. Kelley, Caitlin Y. Su, Jake Leyhr, Katherine S. Morton, Joel N. Meyer, David R. Sherwood#T669 Nonyl Acridine Orange (NAO),ThermoFisher Scientific,Cat. #A1372 FCCP,Cayman Chemical,Cat. #15218 DCCD,Millipore Sigma,Cat. #D80002 DMSO,Millipore Sigma,Cat. # 472301 Critical commercial assays,Critical

(2) Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivoJ ImmunolApril 15, 2026Alicia M. Bostwick-Galaviz, Edward J. Usherwood10 minutes. 50 μL each “Maximum” well were recorded on the ZE5. 50 μL of 2 μM FCCP (Cayman Chemical 15218) in warm RICA buffer were added to the second set of wells (“Minimum”), and cells were incubated at

(3) Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stressbioRxivApril 7, 2026Meini Chen, Eric Weh, Moloy T. Goswami, Katherine M. Weh, Heather Hager, Peter Sajjakulnukit, Avi Weingarten, Shubha Subramanya, Nicholas Miller, Sraboni Chaudhury, et al.MI, USA, Cat #11342), FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Cayman Chemical, Cat #15218) and KCN (Potassium Cyanide, Thermo Fisher, Cat #012136) were injected into the perifusion media at

(4) Mitochondrial acid-sensing ion channel 1a deficiency induces mitochondrial dysfunction in pulmonary arterial smooth muscle cellsAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyApril 1, 2026Megan N. Tuineau, Lindsay M. Herbert, Heaven E. Medina, Jay S. Naik, Thomas C. Resta, Nikki L. Jernigan#,Concentration,Vehicle oligomycin,mitochondrial complex V,Cayman Chemical,11341,1 μM,DMSO FCCP,oxidative phosphorylation,Cayman Chemical,15218,"1, 20 μM",DMSO rotenone,mitochondrial complex I,Cayman Chemical,13995,500 nM,DMSO antimycin A,mitochondrial

(5) Rab12 is a regulator of mitophagy and mitochondrial homeostasisbioRxivMarch 31, 2026Tara Richbourg, Alex George, Anas Bitar, Ian T. Ryde, Casey Farrell, Tuyana Malankhanova, Jennifer Liu, Silas A. Buck, Ivana Barraza, So Young A Kim, et al.final in-well concentration of 1.25μM, 0.1% DMSO. Port B was loaded with 7.2 μM FCCP (Cayman Chemical, 15218), for a final in-well concentration of 0.8 μM, 0.1% DMSO. Port C was loaded with 15 μM Rotenone/Antimycin

(6) Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activityCell ReportsMarch 24, 2026Prabhakar Arumugam, Cortney E. Heim, Rachel W. Fallet, Dhananjay D. Shinde, Vinai C. Thomas, Rafael J. Argüello, Tammy KielianBiotech,130-120-337 2-deoxy-glucose,Cayman Chemical,14325 Oligomycin,Cayman Chemical,11342 FCCP,Cayman Chemical,15218 Rotenone,Cayman Chemical,13995 Antimycin A,Cayman Chemical,34799 RPMI-1640,Cytiva HyClone,SH30027.02 L-Glutamine,Cytiva

(7) S1P-S1PR1 signaling impairs CD8+ T cell metabolism and effector function in tumorsEMBO ReportsMarch 19, 2026Debashree Basak, Puspendu Ghosh, Anupam Gautam, Ishita Sarkar, Arpita Bhoumik, Soham Chowdhury, Shaun Mahanti, Anwesha Mandal, Rajeswari Chakraborty, Anwesha Kar, et al.,Cayman Chemicals,11360-070 Cell-Tak,Corning,354240 Oligomycin,Cayman Chemicals,11341 FCCP,Cayman Chemicals,15218 Rotenone,Cayman Chemicals,13995 Antimycin A,Cayman Chemicals,19433 2-deoxy-D-glucose,Cayman Chemicals,14325 RIPA

(8) Lipopolysaccharide induces HIF-1α accumulation via MAPK p38–mediated mRNA stabilization and dexamethasone-sensitive protein stabilizationJournal of Biological ChemistryFebruary 1, 2026Chloe Lockwood, Kalbinder K. Daley, John D. O’Neil, Katherine J. Heighes, Sally A. Clayton, Andrew R. Clark(C) carbonyl cyanide p-trifluoromethoxyphenylhydrazone (5 μM, Cayman Chemical Company; catalog no.: 15218) + sodium pyruvate (1 mM, Sigma–Aldrich; catalog no.: P5280), and (D) rotenone (100 nM, Cayman Chemical

(9) MRPL47 deficiency drives mitochondrial dysfunction via ROS-p38-p21 signaling in non-small cell lung cancerJournal of Biological ChemistryFebruary 1, 2026Nikita Bhandari, Yengkhom Ghanapriya Devi, Disha Acharya, Vinita Bhat, Annesha Chatterjee, Shweta Yalshetti, Sharathchandra Arandkar, Bal Krishna Chaube, Sudhanshu Shuklarespiration was recorded and then sequential injections of Oligomycin (Cayman #11341), FCCP (Cayman #15218) and Antimycin A (CST #33357) was used to inhibit complexes I and III respectively. Finally, OCR values

(10) IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanomaCancer CellJanuary 22, 2026Triantafyllia Karakousi, Vanessa Cristaldi, Maria Luiza Lopes de Oliveira, Ines Delclaux, Naomi R. Besson, Luiz Henrique Geraldo, Tania J. González-Robles, Devyon R. McDonnough, Daniel Martinez-Krams, Gabrielle da Silva, et al.concentrations of Oligomycin (Cayman Chemical Company, 11342) 2.5umol/L, FCCP (Cayman Chemical Company,15218) 2umol/L, and Antimycin/Rotenone (Sigma Aldrich, A8674/Cayman Chemical Company 13995) 0.5umol/L. Analysis

(11) Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancerCell Rep MedDecember 16, 2025Jody Vykoukal, Yihui Chen, Mingxin Zuo, Riccardo Ballarò, Monica J. Hong, Hansini Krishna, Daniela B. Rodriquez-Perera, Hiroyuki Katayama, Ehsan Irajizad, Ranran Wu, et al.,Cayman Chemical,Cat. 25458 carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP),Cayman Chemical,Cat. 15218 Chloroquine,MedChemExpress,Cat. HY-17589A "cholesterol (ovine wool, >98%)",Avanti Polar Lipids,Cat.

(12) ABCA7 variants impact phosphatidylcholine and mitochondria in neuronsNatureNovember 13, 2025Djuna von Maydell, Shannon E. Wright, Ping-Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, et al.imaging before and immediately after adding the mitochondrial uncoupler FCCP (1 µM; Cayman Chemical, 15218). ROS were assessed by live staining with CellROX Orange (5 µM, 30 min at 37 °C; Thermo Fisher Scientific,

(13) Oxidative-stress-induced telomere instability drives T cell dysfunction in cancerImmunityOctober 14, 2025Dayana B. Rivadeneira, Sanjana Thosar, Kevin Quann, William G. Gunn, Victoria G. Dean, Bingxian Xie, Angelina Parise, Andrew C. McGovern, Kellie Spahr, Konstantinos Lontos, et al.C34571 L-glutamine,Fisher,Cat# MT25005CI Oligomycin Complex,Cayman Chemical,Cat# 11341 FCCP,Cayman Chemical,Cat# 15218 2-deoxy-D-glucose (2DG),Sigma,Cat# D8375-5G Rotenone,Sigma,Cat# R8875-5G Antimycin A,Sigma,Cat# A8674-25MG Recombinant Murine IL-2

(14) Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometryAm J Physiol Renal PhysiolOctober 10, 2025Ryoichi Bessho, Olena Davidoff, Hanako Kobayashi, Volker Hans Haase4-(trifluoromethoxy) phenylhydrazone (FCCP, 50 μM; final concentration of 5 μM, unless specified; #15218, Cayman Chemicals), rotenone and antimycin A combined (50 μM of rotenone; final concentration of 5 μM;

(15) Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imagingbioRxivAugust 12, 2025Lu Ling, Jack C. Crowley, Matthew L. Tan, Jennie A M R Kunitake, Adrian A. Shimpi, Rebecca M. Williams, Lara A. Estroff, Claudia Fischbach, Warren R. Zipfel(KCN),Fisher Chemical,P223I-100 Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP),Cayman Chemical,15218 Streptavidin AlexaFluor-647 conjugate,Life Technologies,S21374 Critical commercial assays,Critical

(16) EZH2 loss during metabolic stress drives restoration of MHC Class I machinery in melanomaiScienceJune 20, 2025Jacob L. Edmondson, Megan R. Reed, Daniel Fil, Billie Heflin, Alyson McKinnon, Michael A. Bauer, Lauren C. Morehead, Nathan L. Avaritt, Mary Phillips, Sean D. Taverna, et al.Oligomycin [APExBio, #A5588] (b) 22μL of 2μM fluoro-carbonyl cyanide phenylhydrazone (FCCP) [Cayman, #15218] (c) 25μL of 0.5μM Rotenone [abcam, #ab143145]/antimycin A. In vitro killing assay CD8+ T cell killing

(17) Mitochondrial Translation Inhibition Uncovers a Critical Metabolic-Epigenetic Interface in Renal Cell CarcinomaMetabolitesJune 12, 2025Kazumi Eckenstein, Beyza Cengiz, Matthew E. K. Chang, Jessie May Cartier, Mark R. Flory, George V. ThomasSeahorse XF96 cartridge was then loaded with Oligomycin (Millipore Sigma #75351), FCCP (Cayman Chemicals #15218), and Rotenone (Millipore Sigma #R8875) + Antimycin-A (Millipore Sigma #A8674). Calibration and measurements

(18) Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survivalElifeMay 21, 2025Moloy T Goswami, Eric Weh, Shubha Subramanya, Katherine M Weh, Hima Bindu Durumutla, Heather Hager, Nicholas Miller, Sraboni Chaudhury, Anthony Andren, Peter Sajjakulnukit, et al.MI, USA, Cat # 11342), FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Cayman Chemical, Cat# 15218), and KCN (Potassium Cyanide, Thermo Fisher, Cat # 012136) were added to the perifusion media through

(19) Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in miceNat CommunMay 8, 2025Omri Yosef, Leonor Cohen-Daniel, Oded Shamriz, Zahala Bar-On, Wajeeh Salaymeh, Amijai Saragovi, Ifat Abramovich, Bella Agranovich, Veronika Lutz, Joseph Tam, et al.used for the OCR measurements: 2 µM Oligomycin (Cayman Chemicals, 11342), 2 µM FCCP (Cayman Chemicals, 15218), and 1 µM Antimycin-A (Cayman Chemicals, 19433) and Rotenone (Cayman Chemicals, 13995). A total of

(20) Rescue of the First Mitochondrial Membrane Carrier, the mPiC, by TAT-Mediated Protein Replacement TreatmentInt J Mol SciMay 5, 2025Samar Zabit, Orly Melloul, Michal Lichtenstein, Erin L. Seifert, Haya Lorberboum-GalskiCayman Chemical, Ann Arbor, MI, USA), 20 µM trifluoromethoxy carbonyl cyanide phenylhydrazone (FCCP) (Cat No. 15218; Cayman Chemical), 10 µM rotenone/antimycin A (Cat No. 13995; Cayman Chemical Santa Cruz Biotechnology,

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FCCP from Cayman Chemical

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