Description
BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC 50 value of 20 µM. BAMB-4 can be used for the research of metastasis of lung cancerIn VitroBAMB-4 (0.3-40 µM) has ITPKA inhibiton effect with an IC 50 value of 37 µM. BAMB-4 (40 µM) inhibits InsP3 kinase activity with an IC 50 value of 20 µM. BAMB-4 (100 µM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 µM) shows increased K m and decreased V max. BAMP-4 (0-30 µM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 37 µM (ITPKA),20 µM (InsP3 kinase)