Gas6 Protein 986-GS-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemGas6 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number986-GS-025
SpeciesMouse
Molecule NameGas6
Quantity25 ug
NCBI Full Gene Namegrowth arrest specific 6
NCBI Gene AliasesGas-6
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 72 kDa, reducing conditions
Theoretical: 62 kDa
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse Gas6 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Available conjugates: Unconjugated

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(2) Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's diseaseJournal of neuroinflammationFebruary 7, 2022Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK.

(3) AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injuryJournal of neuroinflammationJuly 7, 2021Zhou H, Hu L, Li J, Ruan W, Cao Y, Zhuang J, Xu H, Peng Y, Zhang Z, Xu C, et al.

(4) Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarizationThe Journal of clinical investigationJune 1, 2020Shibata T, Makino A, Ogata R, Nakamura S, Ito T, Nagata K, Terauchi Y, Oishi T, Fujieda M, Takahashi Y, et al.

(6) TAM receptors attenuate murine NK-cell responses via E3 ubiquitin ligase Cbl-bEuropean journal of immunologyJanuary 1, 2020Chirino LM, Kumar S, Okumura M, Sterner DE, Mattern M, Butt TR, Kambayashi T.

(7) A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic TargetCellular and molecular gastroenterology and hepatologyJanuary 1, 2020Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, Coll M, Colell A, Gausdal G, Lorens JB, et al.

(9) MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppressionNature communicationsApril 3, 2019Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, et al.

(10) Stromal Gas6 promotes the progression of premalignant mammary cellsOncogeneApril 1, 2019Gomes AM, Carron EC, Mills KL, Dow AM, Gray Z, Fecca CR, Lakey MA, Carmeliet P, Kittrell F, Medina D, et al.

(13) TREM2 Is a Receptor for β-Amyloid that Mediates Microglial FunctionNeuronMarch 7, 2018Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, et al.

(16) TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activationJournal of immunology (Baltimore, Md. : 1950)December 15, 2013Ji R, Tian S, Lu HJ, Lu Q, Zheng Y, Wang X, Ding J, Li Q, Lu Q.

(17) The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cellsMolecular Biology of the CellAugust 15, 2012Hyun-Jung Park, Ji-Yeon Baen, Ye-Ji Lee, Youn-Hee Choi, Jihee Lee Kangthrough the induction of HGF. MATERIALS AND METHODS Reagents Recombinant proteins of mouse Gas6 (986-GS-025), Mer/Fc (591-MR), Axl/Fc (854-AX), Tro3/Fc (759-DT), and Met/Fc (527-ME) were purchased from R&D Systems

(20) Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathwayJournal of immunology (Baltimore, Md. : 1950)September 1, 2009Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M.

Gas6 Protein from R&D Systems, a Bio-Techne Brand