Fig 1: SIGLEC7, SIGLEC9 and SIGLEC10-positive myeloid infiltration is increased in breast tumors and correlates with aggression. A. UMAP projection of immune cells from scRNAseq data of 34 breast tumors [20]. B. Dot plot of SIGLEC expression in immune cell clusters in breast tumors. C. Quantification of i. SIGLEC7, ii. SIGLEC9, and iii. SIGLEC10-positive inflammation as a percentage of total inflammation in normal breast and breast cancer subtypes. D. Quantification of myeloid infiltration as a percentage of total inflammation in normal breast and breast cancer subtypes. E. Heatmap showing the expression of gene signatures in RNAseq data from breast tumors from TCGA. Patients were ordered by the immunosuppressive Siglec signature.