Advanced Oxygen Control Options For Your Critical Culture Studies

Why do I need O₂ Control?
Stem Cell, Oncology, and IVF research are moving towards more closely mimicking in-vivo environmental conditions for optimal results. It has been shown that by creating the hypoxic conditions that cells are subjected to in-vivo, the expression profile and behavior in most cases are radically different than under CO₂ control alone. This makes controlling the O₂ environment critical for assessing the feasibility of many therapies and experiments for clinical applications.

This is why NBS offers three levels of O₂ control. This, combined with our sophisticated and intelligent display design, enables you to put in-vivo conditions in-vitro, with a touch of a button.

Option # 1
1-19% O₂ Control
Customers seeking a hypoxic condition may choose our most popular option. By displacing the Oxygen with Nitrogen, we are able to accurately maintain the low O₂ conditions your cells may require.

1. IVF - Studies have shown the critical importance of low-oxygen tension on development through the maturation, fertilization, and culture stages. (Combine O₂ control with the CO-14 for a personal size dedicated IVF Incubator)

2. Aging Studies/Hypoxic Stress - Hypoxia is related to many pathological conditions: aging, heart and respiratory failure, chronic obstructive pulmonary disease (COPD), diabetes, hypertension and arteriosclerosis. In addition, the human body becomes more susceptible to hypoxia as it ages resulting in tissue degradation.

3. Anaerobic Bacterial Growth - Utilize this option to create an anaerobic chamber without the need for a gas pack. Yersinia, Neiserria, Camplobacter, Heliobacter, and other Enterics are all example of cultures which thrive in our incubators. Expand your capacity by not being limited to anaerobic jars.

Option # 2
0.1-19% O₂ Control
Customers seeking <1% O₂ control may choose this option.

1. Stem Cells - Early-stage stem cells differentiate spontaneously in an ambient O₂ environment. A stringent low O₂ environment allows the researcher to control the stem cell differentiation and maintain full pluripotency of their lines.

Option # 3
1-95% O₂ Control
Customers seeking the utmost versatility and require hyperoxic conditions may choose this option.

Example Applications:
1. Alveolar epithelial and macrophage studies
2. O₂ toxicity studies
3. Mitochondrial ROS production
4. Blood-gas transfer
5. High oxygen tension
6. Fibroblast control

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