Tailoring RNA Oligos To Your Needs

Wednesday June 06, 2007

The most modern technique for knocking out gene function involves the use of double-stranded RNA to silence the expression of your gene of interest, a process known as RNA interference (RNAi). If you want to employ RNAi in your research, you should consider using short interfering RNA (siRNA) molecules. Synthetic siRNAs can be purchased from several companies, including those listed below. Because the efficiency of RNAi depends upon the design of the siRNA molecule, you should determine whether design program will help you come up with the most effective siRNA possible. In addition to being user-friendly, you will want the program to quickly and easily show valuable information such as the position of your siRNA on the mRNA target and its GC content. Integrated sense and antisense BLAST alignment to determine the specificity of the siRNA molecule is also very valuable. Other important features to consider when choosing a siRNA synthesis service are: the method of siRNA purification, the ability to order standard and custom modifications, and quality control methods. Another important thing to remember is the speed of the delivery of the siRNA to your workbench. Check out the vendors listed below and ask about all of the above features before you make a purchase. This will ensure that the siRNA oligo is tailored to your needs.

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Company	Ambion	Invitrogen	B-Bridge International
Item	Custom siRNA, PAGE purified, annealed	BLOCK-iT™ siRNA, Stealth™ and Custom RNA	21-mer duplex
Price	Get Quote	Get Quote	Get Quote
Request Information	Request Info	Request Info	Request Info
Description	Premium quality synthesis and purification You provide the sequence, we'll do the rest Rigorous quality control Your choice of purification method, amount and format ... more	RNA interference (RNAi) was initially proven to be a powerful method of knocking down gene activity by the introduction of a long double-stranded RNA (dsRNA) molecule in invertebrates such as Drosophila and C... more	siSolutions™ siRNA Custom Synthesis Service provides you with high-quality, effective duplex RNA to knockdown any gene. We offer standard 21-mers (19 RNA base pairs with terminal dT nucleotides), the recently-published 27-mers, or other lengths of your choice... more
Catalog Number	AM16304	Request Info	Syn-21-25P
Purity	PAGE purified, annealed	Request Info	desalt & deprotect, purified, >95% purity
Scale	25 nmol	Request Info	25 nmol
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