The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Simply search by “Keywords” if you know the name of the inhibitor, or search by “Inhibitor Target” to enter the name of your protein of interest. Additionally, you may check the appropriate boxes to narrow down your search.
Caspase-3 is a cysteine protease that plays a role in apoptosis, is responsible for chromatin condensation and DNA fragmentation, and may be involved in stem cell differentiation. It is also the predominant caspase involved in cleavage of amyloid-beta, a protein well known for its role in Alzheimer's disease. Caspase-3 interacts with caspase-8 and caspase-9 and shares a substrate with caspase-7. Inhibitors of caspase-3 are in demand for cancer and neurological studies. Members of the IAP (inhibitor of apoptosis) family of protein inhibitors are commonly associated with inhibition of caspase-3.