The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Simply search by “Keywords” if you know the name of the inhibitor, or search by “Inhibitor Target” to enter the name of your protein of interest. Additionally, you may check the appropriate boxes to narrow down your search.
Caspase-4 is a cysteine protease. While much remains to be determined regarding caspase-4’s function and mechanism of action, it is thought to play a role in inflammation and apoptosis related to ER stress. Because ER stress has been linked to ischemia and Alzheimer's, inhibitors to caspase-4 are of interest as therapeutics for these two conditions and various other diseases linked to excessive inflammation and apoptosis. Both peptide and small-molecule caspase-4 inhibitors are available for research purposes.
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