The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Simply search by “Keywords” if you know the name of the inhibitor, or search by “Inhibitor Target” to enter the name of your protein of interest. Additionally, you may check the appropriate boxes to narrow down your search.
Caspases are a family of intracellular cysteine proteases critical to several cellular functions, including apoptosis and inflammation. Mammalian caspases are numbered 1 - 13 and are classified either as initiators or effectors of downstream functions. Pan-caspase inhibitors act on one or more of the known caspases and are pursued for their ability to treat diseases such as autoimmune disorders and cancer. Pan-caspase inhibitors can either be peptides, proteins, or small molecule inhibitors. The small molecule pan-caspase inhibitor VX-166 has garnered interest for its ability to treat fibrosis and sepsis. Several pan-caspase inhibitors can be compared below.