HMGCR ELISA kits are immunoassay tools for the measurement of the protein 3-hydroxy-3-methylglutaryl-CoA reductase, which is encoded by the HMGCR gene in humans. Functionally, this protein is known to catalyze the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. The canonical protein structure is reported to have an amino acid length of 888 residues, a mass of 97.5 kDa, and is a member of the HMG-CoA reductase protein family. It is known to be localized in the ER. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally N-glycosylated, ubiquitinated and phosphorylated. Other alias names for this target include MYPLG, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase, and LDLCQ3.
Some HMGCR ELISA kits can detect targets at levels as low as 0.1 ng/mL and as high as 100 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.