NAGPA ELISA kits are immunoassay tools for the measurement of the protein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, which is encoded by the NAGPA gene in humans. Functionally, this protein is known to catalyze the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. The canonical protein structure is reported to have an amino acid sequence of 515 residues and a mass of 56.1 kDa. It is known to be localized in the golgi. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally cleaved and glycosylated. Other alias names for this target include UCE, alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate-uncovering enzyme, phosphodiester alpha-GlcNAcase, and APAA.
The detection range for different NAGPA ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 10 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.